Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 11199..12145 Replicon plasmid unnamed1
Accession NZ_CP065602
Organism Burkholderia glumae strain FDAARGOS_949

Toxin (Protein)


Gene name slvT Uniprot ID C5AN91
Locus tag I6H06_RS28640 Protein ID WP_012732709.1
Coordinates 11612..12145 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID C5AN90
Locus tag I6H06_RS28635 Protein ID WP_012732708.1
Coordinates 11199..11615 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H06_RS28615 7131..8210 + 1080 WP_012732706.1 ParB N-terminal domain-containing protein -
I6H06_RS28620 8547..9878 + 1332 WP_080942728.1 replication protein O -
I6H06_RS28625 10000..10326 + 327 WP_127913985.1 hypothetical protein -
I6H06_RS28630 10866..11051 + 186 WP_017432454.1 hypothetical protein -
I6H06_RS28635 11199..11615 + 417 WP_012732708.1 DUF2384 domain-containing protein Antitoxin
I6H06_RS28640 11612..12145 + 534 WP_012732709.1 RES family NAD+ phosphorylase Toxin
I6H06_RS28645 12315..12503 + 189 WP_017432455.1 hypothetical protein -
I6H06_RS28650 13255..13539 + 285 WP_017432347.1 hypothetical protein -
I6H06_RS28655 13553..13795 + 243 WP_124837682.1 hypothetical protein -
I6H06_RS28660 13792..14037 + 246 WP_127913916.1 hypothetical protein -
I6H06_RS28665 14094..14435 + 342 WP_012732710.1 hypothetical protein -
I6H06_RS28670 14438..16273 + 1836 WP_045678669.1 site-specific integrase -
I6H06_RS28675 16358..16783 + 426 WP_012734109.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..144540 144540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-168)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19101.61 Da        Isoelectric Point: 4.7118

>T182935 WP_012732709.1 NZ_CP065602:11612-12145 [Burkholderia glumae]
MILTPLQDITAYRMHVPKWAVAPTSGAGAAKAGGRANRIGTPALYLALEAATAVAEYQQLSPLLPPGTLVSYRVTATPVV
DFTGGYRVDLWPPLWESFFCDWRHDWFNARIEPPSWVLGDEAIASGAKGILFRSTQAAGGTNLVLFVDQLGEGDRVDVHD
PAGALPRDQASWVDSPE

Download         Length: 534 bp

>T182935 NZ_CP086622:3071379-3071489 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCCGGCGGGAATTATTACCGCCGCAGC
GATTGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14709.55 Da        Isoelectric Point: 6.4664

>AT182935 WP_012732708.1 NZ_CP065602:11199-11615 [Burkholderia glumae]
MSTLAAARAPAGGPALANFDAFLSALREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPQSASVQQFLREAI
RVIRAATDLSGDVQRALFWYRNEPLAVFDYQTAETLVSAGRADDVVRYVASLEAGAAG

Download         Length: 417 bp

>AT182935 NZ_CP086622:c3071332-3071266 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9GLU3

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9GLX3

References