Detailed information of TA system TA182930

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 208132..208693
• Replicon: chromosome
• Accession: NZ_CP065582
• Organism: Mycoplasma mycoides subsp. capri strain 83/93

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I7640_RS00805
• Protein ID: WP_265496639.1
• Coordinates: 208397..208693 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: L5LA09
• Locus tag: I7640_RS00800
• Protein ID: WP_008362623.1
• Coordinates: 208132..208404 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7640_RS00795 (I7640_00795)	204508..207645	+	3138	WP_265496638.1	ABC transporter substrate-binding protein	-
I7640_RS00800 (I7640_00800)	208132..208404	+	273	WP_008362623.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I7640_RS00805 (I7640_00805)	208397..208693	+	297	WP_265496639.1	type II toxin-antitoxin system YafQ family toxin	Toxin
I7640_RS00810 (I7640_00810)	208729..210009	-	1281	Protein_153	ATP-binding protein	-
I7640_RS00815 (I7640_00815)	210328..211209	+	882	WP_265496640.1	Cof-type HAD-IIB family hydrolase	-
I7640_RS00820 (I7640_00820)	211243..212826	-	1584	WP_265496641.1	LppA family lipoprotein	-
I7640_RS00825 (I7640_00825)	212937..213566	-	630	WP_265496642.1	beta-phosphoglucomutase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-87)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11368.26 Da
• Isoelectric Point: 9.9386

>T182930 WP_265496639.1 NZ_CP065582:208397-208693 [Mycoplasma mycoides subsp. capri]
MTKYKIVTTKFKKDLKLAKKQNKDLNKLDYVINILTQGKELDAKYQDHSLTGIYKGYRECHIDPDLLIYKKDDDKIVITM
LRLGSHSNLFEKQKNY

Nucleotide

• Length: 297 bp

>T182930 NZ_CP086622:1229573-1229908 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10257.67 Da
• Isoelectric Point: 4.8483

>AT182930 WP_008362623.1 NZ_CP065582:208132-208404 [Mycoplasma mycoides subsp. capri]
MKTTNLNVRIDKEVKHDAEAIFNELGLSTSAAINMFFKATIRNNSLPFSTKLDTPNKETLLAMKEAEELLKDPNTKYYSS
FKELLETLDD

Nucleotide

• Length: 273 bp

>AT182930 NZ_CP086622:1229325-1229573 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: L5LA09