Detailed information of TA system TA182926

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 187169..188603
• Replicon: chromosome
• Accession: NZ_CP065576
• Organism: Mycoplasma mycoides subsp. capri strain My-325

Toxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: I7633_RS00795
• Protein ID: WP_265493188.1
• Coordinates: 187169..188008 (-)
• Length: 280 a.a.

Antitoxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: I7633_RS00800
• Protein ID: WP_265509557.1
• Coordinates: 188013..188603 (-)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7633_RS00770 (I7633_00730)	182253..182918	-	666	WP_265493185.1	tRNA (guanosine(46)-N7)-methyltransferase TrmB	-
I7633_RS00775 (I7633_00735)	182920..184323	-	1404	WP_265493186.1	magnesium transporter	-
I7633_RS00785	185003..185410	+	408	WP_265509555.1	hypothetical protein	-
I7633_RS00790	185794..187149	+	1356	WP_265509556.1	hypothetical protein	-
I7633_RS00795 (I7633_00750)	187169..188008	-	840	WP_265493188.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I7633_RS00800 (I7633_00755)	188013..188603	-	591	WP_265509557.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
I7633_RS00805 (I7633_00760)	188875..190128	-	1254	WP_265493190.1	BspA family leucine-rich repeat surface protein	-
I7633_RS00810 (I7633_00765)	190238..192928	-	2691	WP_265493191.1	alanine--tRNA ligase	-
I7633_RS00815 (I7633_00770)	193002..193496	-	495	WP_265493192.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-53)

Sequences

Toxin

Protein

• Length: 280 a.a.
• Molecular weight: 32989.91 Da
• Isoelectric Point: 9.2746

>T182926 WP_265493188.1 NZ_CP065576:c188008-187169 [Mycoplasma mycoides subsp. capri]
MNLQKLKAICKRLSNETKTNYNIILKHYFMISILEKIVKSKNKQNFIIKGGFLLSNMMSLNERTTQDIDCLIKGINFVKE
NILKIISDVLRYDFNDFIEYEIKEITEIKKRDKYNGFRVKILCKLEKLEEIVKIDLVIGDVITPSEIKYNFKNIFSNSSF
EIQAYNLETILAEKIFIINNLNIQSTRIKDLYDIFLIYSLKEFEIDYNILKCACLNTFKKRNTVFNIDLILNLLNEINQL
DIFKLLNNYKQKYFYAQKIEFEILVESVIKLLEKLKSS

Nucleotide

• Length: 840 bp

>T182926 NZ_CP086622:c675487-675023 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23555.30 Da
• Isoelectric Point: 9.4686

>AT182926 WP_265509557.1 NZ_CP065576:c188603-188013 [Mycoplasma mycoides subsp. capri]
MNYKEQLIKEAKKRAGLITRKEIINLKIPSIYITRMIRSNELEKVDIGIYALTSENWYYDPDYNFSIRHKTPIFSYTYAL
TFFDFTDVIPMFRDVTVYHGYNAHNLDPQTRVHYVSKDIYELGVVEVKTNCGNKVRAYDIERTICDFIKHRDKIEAELFA
KTMYKYSEYEKEIEKNFMNMLKKTLVRKFMKFFKY

Nucleotide

• Length: 591 bp

>AT182926 NZ_CP086622:c675822-675487 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA