Detailed information of TA system TA182924

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 197320..198755
• Replicon: chromosome
• Accession: NZ_CP065575
• Organism: Mycoplasma mycoides subsp. capri strain My-I

Toxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: I7632_RS00795
• Protein ID: WP_265511265.1
• Coordinates: 197320..198159 (-)
• Length: 280 a.a.

Antitoxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: I7632_RS00800
• Protein ID: WP_265498407.1
• Coordinates: 198159..198755 (-)
• Length: 199 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7632_RS00775 (I7632_00765)	192403..193068	-	666	WP_265493185.1	tRNA (guanosine(46)-N7)-methyltransferase TrmB	-
I7632_RS00780 (I7632_00770)	193070..194473	-	1404	WP_265493186.1	magnesium transporter	-
I7632_RS00790 (I7632_00780)	195153..197300	+	2148	WP_265493187.1	transglutaminase domain-containing protein	-
I7632_RS00795 (I7632_00785)	197320..198159	-	840	WP_265511265.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I7632_RS00800 (I7632_00790)	198159..198755	-	597	WP_265498407.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
I7632_RS00805 (I7632_00795)	199027..200280	-	1254	WP_265493190.1	BspA family leucine-rich repeat surface protein	-
I7632_RS00810 (I7632_00800)	200390..203080	-	2691	WP_265493191.1	alanine--tRNA ligase	-
I7632_RS00815 (I7632_00805)	203154..203648	-	495	WP_265493192.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-53)

Sequences

Toxin

Protein

• Length: 280 a.a.
• Molecular weight: 32890.77 Da
• Isoelectric Point: 9.1235

>T182924 WP_265511265.1 NZ_CP065575:c198159-197320 [Mycoplasma mycoides subsp. capri]
MNLQKLKAICKGLSNETKTNYNIILKHYFMISILEKIVKSKNKQNFIIKGGFLLSNMMSLNERTTQDIDCLIKGINFVKE
NILKIISDVLRYDFNDFIEYEIKEITEIKKRDKYNGFRVKILCKLEKLEEIVKIDLVIGDVITPSEIKYNFKNIFSNSSF
EIQAYNLETILAEKIFIINNLNIQSTRIKDLYDIFLIYSLKEFEIDYNILKCACLNTFKKRNTVFNIDLILNLLNEINQL
DIFKLLNNYKQKYFYAQKIEFEILVESVIKLLEKLKSS

Nucleotide

• Length: 840 bp

>T182924 NZ_CP086622:262756-262863 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 199 a.a.
• Molecular weight: 23605.24 Da
• Isoelectric Point: 9.3217

>AT182924 WP_265498407.1 NZ_CP065575:c198755-198159 [Mycoplasma mycoides subsp. capri]
MNYKEQLIKEAKKRAGLITRKEIINLKIPSIYITRMIRSNELEKVDIGIYALTSENWYYDPDYNFSIRHKTPIFSYTYAL
TFFDFTDVIPMFRDVTVYHGYNAHNLDPQTRVHYVSKDIYELGVVEVKTNCGNKVRAYDIERTICDFIKHRDKIEAELFA
KTMYKYSEYEKRDKKLHEYAKKMNIGKKVYEVFQVLV

Nucleotide

• Length: 597 bp

>AT182924 NZ_CP086622:c262707-262644 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT