Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-parE/ParE-RHH |
| Location | 1..11736 | Replicon | plasmid unnamed4 |
| Accession | NZ_CP065558 | ||
| Organism | Klebsiella pneumoniae strain FK 6768 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A8J3DTL7 |
| Locus tag | I7S93_RS29340 | Protein ID | WP_071177730.1 |
| Coordinates | 1..315 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A2X1PRM1 |
| Locus tag | I7S93_RS29335 | Protein ID | WP_000093040.1 |
| Coordinates | 11736..13 (+) | Length | -3907.3333333333 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I7S93_RS29340 (I7S93_29145) | 1..315 | + | 315 | WP_071177730.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I7S93_RS29345 (I7S93_29150) | 480..908 | + | 429 | WP_001140599.1 | hypothetical protein | - |
| I7S93_RS29350 (I7S93_29155) | 934..1113 | + | 180 | WP_000165970.1 | Rop family plasmid primer RNA-binding protein | - |
| I7S93_RS29355 (I7S93_29160) | 1140..1670 | - | 531 | WP_071177729.1 | hypothetical protein | - |
| I7S93_RS29360 (I7S93_29165) | 1677..2408 | - | 732 | WP_071177728.1 | MobC family replication-relaxation protein | - |
| I7S93_RS29365 | 2408..3277 | - | 870 | WP_232254647.1 | TraM recognition domain-containing protein | - |
| I7S93_RS29370 | 3343..4005 | - | 663 | WP_232254648.1 | type IV secretory system conjugative DNA transfer family protein | - |
| I7S93_RS29375 | 4230..4376 | - | 147 | WP_232254649.1 | hypothetical protein | - |
| I7S93_RS29380 (I7S93_29175) | 5871..6023 | - | 153 | WP_232254650.1 | colicin release lysis protein | - |
| I7S93_RS29385 (I7S93_29180) | 6109..6366 | - | 258 | WP_032440455.1 | colicin E3-like toxin immunity protein | - |
| I7S93_RS29390 | 6376..6537 | - | 162 | WP_232254643.1 | colicin E3/pyocin S6 family cytotoxin | - |
| I7S93_RS29395 | 6518..6790 | - | 273 | WP_232254644.1 | colicin E3/pyocin S6 family cytotoxin | - |
| I7S93_RS29625 | 6699..6983 | - | 285 | WP_269475550.1 | hypothetical protein | - |
| I7S93_RS29630 | 6953..7177 | - | 225 | WP_269475551.1 | hypothetical protein | - |
| I7S93_RS29405 (I7S93_29190) | 7071..7331 | - | 261 | WP_232254645.1 | colicin-like bacteriocin tRNase domain-containing protein | - |
| I7S93_RS29410 (I7S93_29195) | 7279..7842 | - | 564 | WP_232254651.1 | colicin-like bacteriocin tRNase domain-containing protein | - |
| I7S93_RS29415 (I7S93_29200) | 8173..9662 | - | 1490 | Protein_17 | group II intron reverse transcriptase/maturase | - |
| I7S93_RS29420 (I7S93_29205) | 10308..10553 | + | 246 | WP_032440458.1 | hypothetical protein | - |
| I7S93_RS29425 (I7S93_29210) | 10827..11198 | + | 372 | WP_001237044.1 | cell envelope integrity protein TolA | - |
| I7S93_RS29430 (I7S93_29215) | 11195..11479 | + | 285 | WP_232254646.1 | TonB family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..12001 | 12001 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11805.73 Da Isoelectric Point: 9.8324
>T182922 WP_071177730.1 NZ_CP065558:1-315 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL
Download Length: 315 bp
>T182922 NZ_CP086622:206587-206772 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA
Antitoxin
Download Length: -3907.3333333333 a.a. Molecular weight: 15241.15 Da Isoelectric Point: 4.5486
>AT182922 WP_000093040.1 NZ_CP065558:11736-13 [Klebsiella pneumoniae]
Download Length: -11722 bp
>AT182922 NZ_CP086622:206789-207199 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|