Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1..11736 Replicon plasmid unnamed4
Accession NZ_CP065558
Organism Klebsiella pneumoniae strain FK 6768

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag I7S93_RS29340 Protein ID WP_071177730.1
Coordinates 1..315 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag I7S93_RS29335 Protein ID WP_000093040.1
Coordinates 11736..13 (+) Length -3907.3333333333 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7S93_RS29340 (I7S93_29145) 1..315 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I7S93_RS29345 (I7S93_29150) 480..908 + 429 WP_001140599.1 hypothetical protein -
I7S93_RS29350 (I7S93_29155) 934..1113 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
I7S93_RS29355 (I7S93_29160) 1140..1670 - 531 WP_071177729.1 hypothetical protein -
I7S93_RS29360 (I7S93_29165) 1677..2408 - 732 WP_071177728.1 MobC family replication-relaxation protein -
I7S93_RS29365 2408..3277 - 870 WP_232254647.1 TraM recognition domain-containing protein -
I7S93_RS29370 3343..4005 - 663 WP_232254648.1 type IV secretory system conjugative DNA transfer family protein -
I7S93_RS29375 4230..4376 - 147 WP_232254649.1 hypothetical protein -
I7S93_RS29380 (I7S93_29175) 5871..6023 - 153 WP_232254650.1 colicin release lysis protein -
I7S93_RS29385 (I7S93_29180) 6109..6366 - 258 WP_032440455.1 colicin E3-like toxin immunity protein -
I7S93_RS29390 6376..6537 - 162 WP_232254643.1 colicin E3/pyocin S6 family cytotoxin -
I7S93_RS29395 6518..6790 - 273 WP_232254644.1 colicin E3/pyocin S6 family cytotoxin -
I7S93_RS29625 6699..6983 - 285 WP_269475550.1 hypothetical protein -
I7S93_RS29630 6953..7177 - 225 WP_269475551.1 hypothetical protein -
I7S93_RS29405 (I7S93_29190) 7071..7331 - 261 WP_232254645.1 colicin-like bacteriocin tRNase domain-containing protein -
I7S93_RS29410 (I7S93_29195) 7279..7842 - 564 WP_232254651.1 colicin-like bacteriocin tRNase domain-containing protein -
I7S93_RS29415 (I7S93_29200) 8173..9662 - 1490 Protein_17 group II intron reverse transcriptase/maturase -
I7S93_RS29420 (I7S93_29205) 10308..10553 + 246 WP_032440458.1 hypothetical protein -
I7S93_RS29425 (I7S93_29210) 10827..11198 + 372 WP_001237044.1 cell envelope integrity protein TolA -
I7S93_RS29430 (I7S93_29215) 11195..11479 + 285 WP_232254646.1 TonB family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..12001 12001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-96)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T182922 WP_071177730.1 NZ_CP065558:1-315 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T182922 NZ_CP086622:206587-206772 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: -3907.3333333333 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT182922 WP_000093040.1 NZ_CP065558:11736-13 [Klebsiella pneumoniae]

Download         Length: -11722 bp

>AT182922 NZ_CP086622:206789-207199 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References