Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4920288..4920804 Replicon chromosome
Accession NZ_CP065554
Organism Klebsiella pneumoniae strain FK 6768

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag I7S93_RS24420 Protein ID WP_002886902.1
Coordinates 4920288..4920572 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I7S93_RS24425 Protein ID WP_002886901.1
Coordinates 4920562..4920804 (-) Length 81 a.a.

Genomic Context


I7S93_RS24400I7S93_RS24405I7S93_RS24410I7S93_RS24415I7S93_RS24395I7S93_RS24420I7S93_RS24425I7S93_RS24430I7S93_RS24435I7S93_RS24440
Location: 4916165..4916338 (174 bp)
Type: Others
Protein ID: WP_002886906.1
Location: 4916341..4917084 (744 bp)
Type: Others
Protein ID: WP_002886905.1
Location: 4917441..4919579 (2139 bp)
Type: Others
Protein ID: WP_002886904.1
Location: 4919820..4920284 (465 bp)
Type: Others
Protein ID: WP_002886903.1
Location: 4915772..4916035 (264 bp)
Type: Others
Protein ID: WP_004152271.1
Location: 4920288..4920572 (285 bp)
Type: Toxin
Protein ID: WP_002886902.1
Location: 4920562..4920804 (243 bp)
Type: Antitoxin
Protein ID: WP_002886901.1
Location: 4920882..4922792 (1911 bp)
Type: Others
Protein ID: WP_004152270.1
Location: 4922815..4923969 (1155 bp)
Type: Others
Protein ID: WP_002886900.1
Location: 4924035..4924775 (741 bp)
Type: Others
Protein ID: WP_002886899.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I7S93_RS24395 (I7S93_24330)4915772..4916035-264WP_004152271.1PTS sugar transporter subunit IIB-
I7S93_RS24400 (I7S93_24335)4916165..4916338+174WP_002886906.1hypothetical protein-
I7S93_RS24405 (I7S93_24340)4916341..4917084+744WP_002886905.1MurR/RpiR family transcriptional regulator-
I7S93_RS24410 (I7S93_24345)4917441..4919579+2139WP_002886904.1anaerobic ribonucleoside-triphosphate reductase-
I7S93_RS24415 (I7S93_24350)4919820..4920284+465WP_002886903.1anaerobic ribonucleoside-triphosphate reductase-activating protein-
I7S93_RS24420 (I7S93_24355)4920288..4920572-285WP_002886902.1type II toxin-antitoxin system RelE/ParE family toxinToxin
I7S93_RS24425 (I7S93_24360)4920562..4920804-243WP_002886901.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
I7S93_RS24430 (I7S93_24365)4920882..4922792-1911WP_004152270.1PRD domain-containing protein-
I7S93_RS24435 (I7S93_24370)4922815..4923969-1155WP_002886900.1lactonase family protein-
I7S93_RS24440 (I7S93_24375)4924035..4924775-741WP_002886899.1KDGP aldolase family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T182917 WP_002886902.1 NZ_CP065554:c4920572-4920288 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T182917 NZ_CP086620:c4732441-4732268 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT182917 WP_002886901.1 NZ_CP065554:c4920804-4920562 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT182917 NZ_CP086620:c4732765-4732469 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GMH2


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GLP0

References