182917

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4920288..4920804 Replicon chromosome
Accession NZ_CP065554
Organism Klebsiella pneumoniae strain FK 6768

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag I7S93_RS24420 Protein ID WP_002886902.1
Coordinates 4920288..4920572 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I7S93_RS24425 Protein ID WP_002886901.1
Coordinates 4920562..4920804 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7S93_RS24395 (I7S93_24330) 4915772..4916035 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
I7S93_RS24400 (I7S93_24335) 4916165..4916338 + 174 WP_002886906.1 hypothetical protein -
I7S93_RS24405 (I7S93_24340) 4916341..4917084 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I7S93_RS24410 (I7S93_24345) 4917441..4919579 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
I7S93_RS24415 (I7S93_24350) 4919820..4920284 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I7S93_RS24420 (I7S93_24355) 4920288..4920572 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I7S93_RS24425 (I7S93_24360) 4920562..4920804 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I7S93_RS24430 (I7S93_24365) 4920882..4922792 - 1911 WP_004152270.1 PRD domain-containing protein -
I7S93_RS24435 (I7S93_24370) 4922815..4923969 - 1155 WP_002886900.1 lactonase family protein -
I7S93_RS24440 (I7S93_24375) 4924035..4924775 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T182917 WP_002886902.1 NZ_CP065554:c4920572-4920288 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T182917 NZ_CP086620:c4732441-4732268 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT182917 WP_002886901.1 NZ_CP065554:c4920804-4920562 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT182917 NZ_CP086620:c4732765-4732469 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References