182905

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876584..877238 Replicon chromosome
Accession NZ_CP065554
Organism Klebsiella pneumoniae strain FK 6768

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag I7S93_RS04425 Protein ID WP_004144731.1
Coordinates 876831..877238 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I7S93_RS04420 Protein ID WP_002916312.1
Coordinates 876584..876850 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7S93_RS04395 (I7S93_04390) 871740..873173 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
I7S93_RS04400 (I7S93_04395) 873292..874020 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I7S93_RS04405 (I7S93_04400) 874070..874381 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
I7S93_RS04410 (I7S93_04405) 874545..875204 + 660 WP_002916317.1 hemolysin III family protein -
I7S93_RS04415 (I7S93_04410) 875355..876338 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I7S93_RS04420 (I7S93_04415) 876584..876850 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I7S93_RS04425 (I7S93_04420) 876831..877238 + 408 WP_004144731.1 protein YgfX Toxin
I7S93_RS04430 (I7S93_04425) 877245..877766 - 522 WP_002916308.1 flavodoxin FldB -
I7S93_RS04435 (I7S93_04430) 877867..878763 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I7S93_RS04440 (I7S93_04435) 878786..879499 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I7S93_RS04445 (I7S93_04440) 879505..881238 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T182905 WP_004144731.1 NZ_CP065554:876831-877238 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T182905 NZ_CP086620:2418582-2418685 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT182905 WP_002916312.1 NZ_CP065554:876584-876850 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT182905 NZ_CP086620:c2418723-2418452 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References