Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 218093..218622 Replicon chromosome
Accession NZ_CP065547
Organism Enterococcus faecium strain Dallas

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag I7089_RS01075 Protein ID WP_002296560.1
Coordinates 218356..218622 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag I7089_RS01070 Protein ID WP_002296559.1
Coordinates 218093..218356 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7089_RS01060 215467..217290 + 1824 WP_002294202.1 APC family permease -
I7089_RS01065 217432..217617 - 186 WP_002296558.1 transcriptional regulator -
I7089_RS01070 218093..218356 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I7089_RS01075 218356..218622 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
I7089_RS01080 218823..219311 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
I7089_RS01085 219852..220523 - 672 WP_002302663.1 ABC transporter permease -
I7089_RS01090 220520..221437 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
I7089_RS01095 221434..222075 - 642 WP_002293405.1 ABC transporter permease -
I7089_RS01100 222079..223254 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T182896 WP_002296560.1 NZ_CP065547:218356-218622 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T182896 NZ_CP086620:262336-262443 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT182896 WP_002296559.1 NZ_CP065547:218093-218356 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT182896 NZ_CP086620:c262278-262224 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References