Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1783479..1783972 Replicon chromosome
Accession NZ_CP065535
Organism Enterococcus durans strain KCTC 13289

Toxin (Protein)


Gene name relE Uniprot ID A0A2A7SNY0
Locus tag I4Q39_RS08335 Protein ID WP_005880058.1
Coordinates 1783479..1783745 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A7SN65
Locus tag I4Q39_RS08340 Protein ID WP_005880060.1
Coordinates 1783742..1783972 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I4Q39_RS08315 1779560..1780942 - 1383 WP_016176480.1 tyrosine-type recombinase/integrase -
I4Q39_RS08320 1781129..1781325 + 197 Protein_1632 hypothetical protein -
I4Q39_RS08325 1781502..1782203 - 702 WP_016176479.1 hypothetical protein -
I4Q39_RS08330 1782337..1783296 - 960 WP_002322607.1 IS30-like element IS6770 family transposase -
I4Q39_RS08335 1783479..1783745 - 267 WP_005880058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I4Q39_RS08340 1783742..1783972 - 231 WP_005880060.1 hypothetical protein Antitoxin
I4Q39_RS08345 1784183..1784335 + 153 WP_080391666.1 putative holin-like toxin -
I4Q39_RS08350 1784570..1784788 - 219 WP_016176477.1 hypothetical protein -
I4Q39_RS08355 1784960..1785223 - 264 WP_016176476.1 hypothetical protein -
I4Q39_RS08360 1785325..1786083 - 759 WP_060789925.1 restriction endonuclease -
I4Q39_RS08365 1786418..1787443 - 1026 WP_016176475.1 HNH endonuclease -
I4Q39_RS08370 1788056..1788217 - 162 WP_016176474.1 hypothetical protein -
I4Q39_RS08375 1788210..1788776 - 567 WP_016176473.1 zeta toxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1782337..1783296 959
- flank IS/Tn - - 1788881..1789792 911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10563.16 Da        Isoelectric Point: 10.0944

>T182892 WP_005880058.1 NZ_CP065535:c1783745-1783479 [Enterococcus durans]
VTYHLEFTPEIQKQLRKMDKYQATLIVRWLYQHIDGVDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQMVVIAIQV
GHRRNVYD

Download         Length: 267 bp

>T182892 NZ_CP086619:57659-57934 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTATGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8850.03 Da        Isoelectric Point: 4.2583

>AT182892 WP_005880060.1 NZ_CP065535:c1783972-1783742 [Enterococcus durans]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWIESGKPTVSMEEILNEFGGLK

Download         Length: 231 bp

>AT182892 NZ_CP086619:57375-57659 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7SNY0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7SN65

References