Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 1079603..1080122 Replicon chromosome
Accession NZ_CP065535
Organism Enterococcus durans strain KCTC 13289

Toxin (Protein)


Gene name Txe Uniprot ID A0A377L4K5
Locus tag I4Q39_RS05125 Protein ID WP_005878588.1
Coordinates 1079865..1080122 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A367CD15
Locus tag I4Q39_RS05120 Protein ID WP_005878590.1
Coordinates 1079603..1079872 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I4Q39_RS05085 1074727..1075614 + 888 WP_005878604.1 site-specific tyrosine recombinase XerD -
I4Q39_RS05090 1075633..1076004 + 372 WP_005878601.1 GNAT family N-acetyltransferase -
I4Q39_RS05095 1076001..1076771 + 771 WP_025479929.1 segregation/condensation protein A -
I4Q39_RS05100 1076755..1077330 + 576 WP_016176830.1 SMC-Scp complex subunit ScpB -
I4Q39_RS05105 1077330..1078046 + 717 WP_005878594.1 rRNA pseudouridine synthase -
I4Q39_RS05110 1078378..1078986 + 609 WP_005878592.1 ECF transporter S component -
I4Q39_RS05115 1079399..1079545 + 147 WP_155854551.1 hypothetical protein -
I4Q39_RS05120 1079603..1079872 + 270 WP_005878590.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I4Q39_RS05125 1079865..1080122 + 258 WP_005878588.1 Txe/YoeB family addiction module toxin Toxin
I4Q39_RS05130 1080518..1081084 + 567 WP_016176829.1 hypothetical protein -
I4Q39_RS05135 1081099..1081545 + 447 WP_016176828.1 hypothetical protein -
I4Q39_RS05140 1082240..1083763 + 1524 WP_005878582.1 YfcC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10274.61 Da        Isoelectric Point: 9.2515

>T182890 WP_005878588.1 NZ_CP065535:1079865-1080122 [Enterococcus durans]
MIKAWSDDAWNDYLYWYEQGNKSNIKKINKLIKDIDRSPFNGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T182890 NZ_CP086618:c4711435-4711262 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10402.60 Da        Isoelectric Point: 4.7051

>AT182890 WP_005878590.1 NZ_CP065535:1079603-1079872 [Enterococcus durans]
MEAVSYSNFRKNLRGYMKQVNEDAETLIVTSKDVDDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGTFKKH
DLIEVESDD

Download         Length: 270 bp

>AT182890 NZ_CP086618:c4711759-4711463 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377L4K5

Antitoxin

Source ID Structure
AlphaFold DB A0A367CD15

References