Detailed information of TA system TA182885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1091851..1092475
• Replicon: chromosome
• Accession: NZ_CP065534
• Organism: Lonsdalea populi strain N-5-1

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: E0SD87
• Locus tag: I6N93_RS04865
• Protein ID: WP_009114000.1
• Coordinates: 1091851..1092054 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: I6N93_RS04870
• Protein ID: WP_085689888.1
• Coordinates: 1092107..1092475 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6N93_RS04835	1087482..1087820	+	339	WP_009114005.1	P-II family nitrogen regulator	-
I6N93_RS04840	1087861..1089153	+	1293	WP_085689883.1	ammonium transporter AmtB	-
I6N93_RS04845	1089258..1090121	-	864	WP_085689915.1	acyl-CoA thioesterase II	-
I6N93_RS04850	1090331..1090903	+	573	WP_085689885.1	YbaY family lipoprotein	-
I6N93_RS04855	1090924..1091244	-	321	WP_085689887.1	MGMT family protein	-
I6N93_RS04865	1091851..1092054	-	204	WP_009114000.1	hemolysin expression modulator Hha	Toxin
I6N93_RS04870	1092107..1092475	-	369	WP_085689888.1	Hha toxicity modulator TomB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-115)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8133.51 Da
• Isoelectric Point: 8.8500

>T182885 WP_009114000.1 NZ_CP065534:c1092054-1091851 [Lonsdalea populi]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Nucleotide

• Length: 204 bp

>T182885 NZ_CP086618:3902501-3902719 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14408.15 Da
• Isoelectric Point: 4.7628

>AT182885 WP_085689888.1 NZ_CP065534:c1092475-1092107 [Lonsdalea populi]
MDEYSPKHYDIAQLRFLCENLRDESIATLGDSNHGWVNDPTSAINLQLNELIEHIAAFIGTYKIKYPDDEELYMRVEKYL
DDTYILFSNYGINDAELRRWQKSKSQLFRMLSEKSNYATVRT

Nucleotide

• Length: 369 bp

>AT182885 NZ_CP086618:3902101-3902475 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A1X3RNQ0