Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2601637..2602166 Replicon chromosome
Accession NZ_CP065523
Organism Enterococcus faecium strain VRE3389

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag ISU51_RS12745 Protein ID WP_002296560.1
Coordinates 2601637..2601903 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag ISU51_RS12750 Protein ID WP_002296559.1
Coordinates 2601903..2602166 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU51_RS12715 2597037..2597441 - 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -
ISU51_RS12720 2597599..2598180 + 582 Protein_2451 CBS domain-containing protein -
ISU51_RS12725 2598184..2598825 + 642 WP_002293405.1 ABC transporter permease -
ISU51_RS12730 2598822..2599739 + 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
ISU51_RS12735 2599736..2600407 + 672 WP_002302663.1 ABC transporter permease -
ISU51_RS12740 2600948..2601436 - 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
ISU51_RS12745 2601637..2601903 - 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
ISU51_RS12750 2601903..2602166 - 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ISU51_RS12755 2602642..2602827 + 186 WP_002296558.1 transcriptional regulator -
ISU51_RS12760 2602969..2604792 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T182870 WP_002296560.1 NZ_CP065523:c2601903-2601637 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T182870 NZ_CP086618:262820-262927 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT182870 WP_002296559.1 NZ_CP065523:c2602166-2601903 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT182870 NZ_CP086618:c262771-262708 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References