Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
Location | 2317324..2317895 | Replicon | chromosome |
Accession | NZ_CP065523 | ||
Organism | Enterococcus faecium strain VRE3389 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | Q3Y2B8 |
Locus tag | ISU51_RS11430 | Protein ID | WP_002286801.1 |
Coordinates | 2317324..2317665 (-) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A828ZZN9 |
Locus tag | ISU51_RS11435 | Protein ID | WP_002323011.1 |
Coordinates | 2317665..2317895 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ISU51_RS11405 | 2312535..2313869 | - | 1335 | WP_002333419.1 | ABC transporter substrate-binding protein | - |
ISU51_RS11410 | 2314076..2314906 | + | 831 | WP_002286789.1 | manganese catalase family protein | - |
ISU51_RS11415 | 2315150..2315432 | - | 283 | Protein_2193 | transposase | - |
ISU51_RS11420 | 2315590..2315784 | - | 195 | WP_002295146.1 | hypothetical protein | - |
ISU51_RS11425 | 2316289..2316474 | - | 186 | WP_002304207.1 | hypothetical protein | - |
ISU51_RS11430 | 2317324..2317665 | - | 342 | WP_002286801.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
ISU51_RS11435 | 2317665..2317895 | - | 231 | WP_002323011.1 | hypothetical protein | Antitoxin |
ISU51_RS11440 | 2318182..2318520 | + | 339 | WP_002286804.1 | hypothetical protein | - |
ISU51_RS11445 | 2318725..2319300 | - | 576 | WP_002293673.1 | SOS response-associated peptidase family protein | - |
ISU51_RS11450 | 2319909..2320490 | - | 582 | WP_002286813.1 | TetR/AcrR family transcriptional regulator | - |
ISU51_RS11455 | 2320673..2321299 | - | 627 | WP_002333420.1 | cysteine hydrolase | - |
ISU51_RS11460 | 2321321..2322652 | - | 1332 | WP_002286818.1 | FAD-containing oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13302.68 Da Isoelectric Point: 9.9044
>T182869 WP_002286801.1 NZ_CP065523:c2317665-2317324 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF
Download Length: 342 bp
>T182869 NZ_CP086618:262336-262443 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8523.39 Da Isoelectric Point: 3.9078
>AT182869 WP_002323011.1 NZ_CP065523:c2317895-2317665 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL
Download Length: 231 bp
>AT182869 NZ_CP086618:c262278-262224 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FD66 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZZN9 |