Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 945682..946159 Replicon chromosome
Accession NZ_CP065515
Organism Staphylococcus aureus strain GDY8P96A

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IQE12_RS04615 Protein ID WP_000052076.1
Coordinates 945682..945870 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IQE12_RS04620 Protein ID WP_001059690.1
Coordinates 945899..946159 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQE12_RS04585 941672..942193 + 522 WP_000824464.1 hypothetical protein -
IQE12_RS04590 942534..943220 + 687 WP_001793574.1 thermonuclease family protein -
IQE12_RS04595 943577..943777 + 201 WP_001059082.1 cold-shock protein -
IQE12_RS04600 944273..944491 - 219 WP_000005886.1 hypothetical protein -
IQE12_RS04605 944553..944837 - 285 WP_001004401.1 hypothetical protein -
IQE12_RS04610 944925..945494 - 570 WP_001106654.1 hypothetical protein -
IQE12_RS04615 945682..945870 - 189 WP_000052076.1 hypothetical protein Toxin
IQE12_RS04620 945899..946159 - 261 WP_001059690.1 hypothetical protein Antitoxin
IQE12_RS04625 946499..946702 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IQE12_RS04630 946699..946935 - 237 WP_000368687.1 hypothetical protein -
IQE12_RS04635 947159..947740 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
IQE12_RS04640 947813..948430 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
IQE12_RS04645 948585..949079 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
IQE12_RS04650 949478..949900 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
IQE12_RS04655 950048..950764 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T182855 WP_000052076.1 NZ_CP065515:c945870-945682 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T182855 NZ_CP086616:2976387-2976494 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT182855 WP_001059690.1 NZ_CP065515:c946159-945899 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT182855 NZ_CP086616:c2976337-2976274 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References