Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2844899..2845817 Replicon chromosome
Accession NZ_CP065511
Organism Cytobacillus oceanisediminis strain N497-ZHONG

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag IRB79_RS14410 Protein ID WP_243503161.1
Coordinates 2844899..2845663 (+) Length 255 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID -
Locus tag IRB79_RS14415 Protein ID WP_243503162.1
Coordinates 2845644..2845817 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRB79_RS14390 (IRB79_14350) 2840149..2840880 - 732 WP_243503157.1 3-deoxy-manno-octulosonate cytidylyltransferase -
IRB79_RS14395 (IRB79_14355) 2841083..2842645 - 1563 WP_243503158.1 TetR family transcriptional regulator C-terminal domain-containing protein -
IRB79_RS14400 (IRB79_14360) 2843121..2843573 + 453 WP_243503159.1 hypothetical protein -
IRB79_RS14405 (IRB79_14365) 2843680..2844474 - 795 WP_243503160.1 PHP domain-containing protein -
IRB79_RS14410 (IRB79_14370) 2844899..2845663 + 765 WP_243503161.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
IRB79_RS14415 (IRB79_14375) 2845644..2845817 + 174 WP_243503162.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
IRB79_RS14420 (IRB79_14380) 2846091..2847461 - 1371 WP_243503163.1 aldehyde dehydrogenase -
IRB79_RS14425 (IRB79_14385) 2847583..2848179 - 597 WP_243503164.1 flavin reductase family protein -
IRB79_RS14430 (IRB79_14390) 2848200..2849447 - 1248 WP_243503165.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(6-57)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29971.66 Da        Isoelectric Point: 4.3116

>T182851 WP_243503161.1 NZ_CP065511:2844899-2845663 [Cytobacillus oceanisediminis]
MLLFFKIVVWMIVACLGFYVFSVWRWEKKVKERMFAIRKTWYIIYVLGAVIYWTKVPESIFTDWLNYLIVAIIFALVDAF
IFLGSYLKRVGNNELATDTMELLEENNDLLNSQMNKLKSFQYLLKNEPIDVYYGDMEAYIAGIEKLLADYAEKVDMKASL
CKYTTQEDKDYLLEHYPDKALIHSRLDRKEVYYDADEKLALIPFSILEDYYVIKLTSDDFVTEFDYLLFTSLISIYDLML
PAEQEDEDHEGTSG

Download         Length: 765 bp

>T182851 NZ_CP086616:2319486-2319589 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6738.98 Da        Isoelectric Point: 10.8769

>AT182851 WP_243503162.1 NZ_CP065511:2845644-2845817 [Cytobacillus oceanisediminis]
MKEPADKEKHKLSTKNNMKIMKKKSRINLPDFEVSPHTERIIKENKRLISVYTKSKA

Download         Length: 174 bp

>AT182851 NZ_CP086616:c2319627-2319356 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References