Detailed information of TA system TA182851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 2844899..2845817
• Replicon: chromosome
• Accession: NZ_CP065511
• Organism: Cytobacillus oceanisediminis strain N497-ZHONG

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: IRB79_RS14410
• Protein ID: WP_243503161.1
• Coordinates: 2844899..2845663 (+)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: -
• Locus tag: IRB79_RS14415
• Protein ID: WP_243503162.1
• Coordinates: 2845644..2845817 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRB79_RS14390 (IRB79_14350)	2840149..2840880	-	732	WP_243503157.1	3-deoxy-manno-octulosonate cytidylyltransferase	-
IRB79_RS14395 (IRB79_14355)	2841083..2842645	-	1563	WP_243503158.1	TetR family transcriptional regulator C-terminal domain-containing protein	-
IRB79_RS14400 (IRB79_14360)	2843121..2843573	+	453	WP_243503159.1	hypothetical protein	-
IRB79_RS14405 (IRB79_14365)	2843680..2844474	-	795	WP_243503160.1	PHP domain-containing protein	-
IRB79_RS14410 (IRB79_14370)	2844899..2845663	+	765	WP_243503161.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
IRB79_RS14415 (IRB79_14375)	2845644..2845817	+	174	WP_243503162.1	type II toxin-antitoxin system SpoIISB family antitoxin	Antitoxin
IRB79_RS14420 (IRB79_14380)	2846091..2847461	-	1371	WP_243503163.1	aldehyde dehydrogenase	-
IRB79_RS14425 (IRB79_14385)	2847583..2848179	-	597	WP_243503164.1	flavin reductase family protein	-
IRB79_RS14430 (IRB79_14390)	2848200..2849447	-	1248	WP_243503165.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-239)

Antitoxin

• Antitoxin SpoIISB (6-57)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29971.66 Da
• Isoelectric Point: 4.3116

>T182851 WP_243503161.1 NZ_CP065511:2844899-2845663 [Cytobacillus oceanisediminis]
MLLFFKIVVWMIVACLGFYVFSVWRWEKKVKERMFAIRKTWYIIYVLGAVIYWTKVPESIFTDWLNYLIVAIIFALVDAF
IFLGSYLKRVGNNELATDTMELLEENNDLLNSQMNKLKSFQYLLKNEPIDVYYGDMEAYIAGIEKLLADYAEKVDMKASL
CKYTTQEDKDYLLEHYPDKALIHSRLDRKEVYYDADEKLALIPFSILEDYYVIKLTSDDFVTEFDYLLFTSLISIYDLML
PAEQEDEDHEGTSG

Nucleotide

• Length: 765 bp

>T182851 NZ_CP086616:2319486-2319589 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6738.98 Da
• Isoelectric Point: 10.8769

>AT182851 WP_243503162.1 NZ_CP065511:2845644-2845817 [Cytobacillus oceanisediminis]
MKEPADKEKHKLSTKNNMKIMKKKSRINLPDFEVSPHTERIIKENKRLISVYTKSKA

Nucleotide

• Length: 174 bp

>AT182851 NZ_CP086616:c2319627-2319356 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT