Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 501149..501785 Replicon chromosome
Accession NZ_CP065511
Organism Cytobacillus oceanisediminis strain N497-ZHONG

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag IRB79_RS02610 Protein ID WP_009336311.1
Coordinates 501435..501785 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W7L1R3
Locus tag IRB79_RS02605 Protein ID WP_035331931.1
Coordinates 501149..501430 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRB79_RS02585 (IRB79_02590) 497195..497920 - 726 WP_243506591.1 rhomboid family intramembrane serine protease -
IRB79_RS02590 (IRB79_02595) 498085..498438 + 354 WP_243506592.1 holo-ACP synthase -
IRB79_RS02595 (IRB79_02600) 498583..499596 + 1014 WP_221881344.1 outer membrane lipoprotein carrier protein LolA -
IRB79_RS02600 (IRB79_02605) 499776..500933 + 1158 WP_243506595.1 alanine racemase -
IRB79_RS02605 (IRB79_02610) 501149..501430 + 282 WP_035331931.1 YlcI/YnfO family protein Antitoxin
IRB79_RS02610 (IRB79_02615) 501435..501785 + 351 WP_009336311.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
IRB79_RS02615 (IRB79_02620) 502165..502998 + 834 WP_243506596.1 RsbT co-antagonist protein RsbRA -
IRB79_RS02620 (IRB79_02625) 502995..503357 + 363 WP_009336309.1 STAS domain-containing protein -
IRB79_RS02625 (IRB79_02630) 503362..503763 + 402 WP_026580738.1 anti-sigma regulatory factor -
IRB79_RS02630 (IRB79_02635) 503775..504785 + 1011 WP_243506597.1 PP2C family protein-serine/threonine phosphatase -
IRB79_RS02635 (IRB79_02640) 504846..505178 + 333 WP_009336305.1 anti-sigma factor antagonist -
IRB79_RS02640 (IRB79_02645) 505175..505648 + 474 WP_009336304.1 anti-sigma B factor RsbW -
IRB79_RS02645 (IRB79_02650) 505626..506420 + 795 WP_243506598.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T182850 WP_009336311.1 NZ_CP065511:501435-501785 [Cytobacillus oceanisediminis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

>T182850 NZ_CP086616:1318772-1319083 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10831.33 Da        Isoelectric Point: 7.2028

>AT182850 WP_035331931.1 NZ_CP065511:501149-501430 [Cytobacillus oceanisediminis]
VSESSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT182850 NZ_CP086616:1319080-1319499 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A169FD46

Antitoxin

Source ID Structure
AlphaFold DB W7L1R3

References