Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 946717..947374 Replicon chromosome
Accession NZ_CP065474
Organism Klebsiella michiganensis strain 7525

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag I6F39_RS04610 Protein ID WP_004854060.1
Coordinates 946964..947374 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag I6F39_RS04605 Protein ID WP_004124953.1
Coordinates 946717..946983 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6F39_RS04590 941969..942394 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
I6F39_RS04595 942515..945313 - 2799 WP_197663981.1 sigma-54-dependent transcriptional regulator -
I6F39_RS04600 945489..946472 - 984 WP_004854063.1 tRNA-modifying protein YgfZ -
I6F39_RS04605 946717..946983 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
I6F39_RS04610 946964..947374 + 411 WP_004854060.1 protein YgfX Toxin
I6F39_RS04615 947383..947904 - 522 WP_009654974.1 flavodoxin FldB -
I6F39_RS04620 948026..948922 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
I6F39_RS04625 948945..949658 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6F39_RS04630 949664..951397 + 1734 WP_004854053.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T182836 WP_004854060.1 NZ_CP065474:946964-947374 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T182836 NZ_CP086614:14650-14844 [Shinella zoogloeoides]
ATACCTTGGCGCGACATCGAGGCCATGCTGGCCGCATGTGGGGCGGAAATTACGGAAGGGCAAGGGTCGCGTGTCCGCAT
AGCCTTGAATGGCGTGCGTGCGGTGTTTCACCGGCCTCATCCGCAAAAAGAAACGGATAAGGGTGCGGTGAAATCCGTCC
GGCGCTTCCTGCTCGAAGCGGAGATACAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT182836 WP_004124953.1 NZ_CP065474:946717-946983 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT182836 NZ_CP086614:14841-15170 [Shinella zoogloeoides]
ATGACCATGATGCACTACAAGGGCTATGAAGCTGTCGTCGAGTTCGACGAGGAGGCCGAGATTTTTCACGGCGAAGTCAT
CAACCTGCGCGATGTGATTACCTTCCAGGGCGCATCGGCGGCCGAACTGAAGCAAGCATTTGCGGAATCTGTCGAGGATT
ACCTGGCATTCTGCGCCGAGCGCGGCGAGGAACCGGAAAAGCCCTTCTCCGGACAGTTCGTGGTGCGTACCGAACCAGGC
TTGCATAAAGCGCTGACGGTGGCCGCCCGCCGTGCCGGTGTCAGCCTGAACAAATGGGTCACATCCACGCTGGAACGGGC
GGTCGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References