Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2651494..2652113 Replicon chromosome
Accession NZ_CP065467
Organism Klebsiella quasipneumoniae strain Pinhead Larry

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I5M56_RS12720 Protein ID WP_002892050.1
Coordinates 2651895..2652113 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I5M56_RS12715 Protein ID WP_002892066.1
Coordinates 2651494..2651868 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M56_RS12705 2646647..2647840 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I5M56_RS12710 2647863..2651009 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
I5M56_RS12715 2651494..2651868 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I5M56_RS12720 2651895..2652113 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I5M56_RS12725 2652272..2652838 + 567 WP_004204750.1 maltose O-acetyltransferase -
I5M56_RS12730 2652810..2652932 - 123 WP_032426076.1 hypothetical protein -
I5M56_RS12735 2652975..2653445 + 471 WP_004204751.1 YlaC family protein -
I5M56_RS12740 2653414..2654871 - 1458 WP_048294265.1 PLP-dependent aminotransferase family protein -
I5M56_RS12745 2654972..2655670 + 699 WP_108450647.1 GNAT family N-acetyltransferase -
I5M56_RS12750 2655667..2655807 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I5M56_RS12755 2655807..2656070 - 264 WP_108450648.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T182823 WP_002892050.1 NZ_CP065467:2651895-2652113 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T182823 NZ_CP086604:4181979-4182131 [Escherichia fergusonii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT182823 WP_002892066.1 NZ_CP065467:2651494-2651868 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT182823 NZ_CP086604:c4181937-4181885 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References