Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4452331..4452985 Replicon chromosome
Accession NZ_CP065464
Organism Klebsiella pneumoniae strain Olaf

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag I5M57_RS21940 Protein ID WP_004144731.1
Coordinates 4452331..4452738 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I5M57_RS21945 Protein ID WP_002916312.1
Coordinates 4452719..4452985 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M57_RS21920 4448331..4450064 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
I5M57_RS21925 4450070..4450783 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I5M57_RS21930 4450806..4451702 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I5M57_RS21935 4451803..4452324 + 522 WP_002916308.1 flavodoxin FldB -
I5M57_RS21940 4452331..4452738 - 408 WP_004144731.1 protein YgfX Toxin
I5M57_RS21945 4452719..4452985 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I5M57_RS21950 4453231..4454214 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I5M57_RS21955 4454365..4455024 - 660 WP_002916317.1 hemolysin III family protein -
I5M57_RS21960 4455188..4455499 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
I5M57_RS21965 4455549..4456277 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I5M57_RS21970 4456396..4457829 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T182802 WP_004144731.1 NZ_CP065464:c4452738-4452331 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T182802 NZ_CP086592:2954845-2955009 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAACTATCGTTTATTGTACAACATATGAAACAATTCAGACGATCCTTGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAGAAGACAACAGAAATGACCGCTGTTTAACTTTGGCTA
GTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT182802 WP_002916312.1 NZ_CP065464:c4452985-4452719 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT182802 NZ_CP086592:c2954843-2954658 [Enterococcus faecalis]
TGCTACAATAGAAACGAAAAGAGAGGTATGCTGTAACATACCTCTCTAATGTAGAACCGTTTAAGACGGTGACCATGTTA
ATTATTTAAAAATAACCGTACTCGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCGC
AATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References