Detailed information of TA system TA182781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5380898..5382579
• Replicon: chromosome
• Accession: NZ_CP065460
• Organism: Klebsiella pneumoniae strain Gordon

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: I5M58_RS26715
• Protein ID: WP_002885155.1
• Coordinates: 5380898..5381815 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W8UPQ8
• Locus tag: I5M58_RS26720
• Protein ID: WP_004151732.1
• Coordinates: 5381821..5382579 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5M58_RS26695	5376204..5377724	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
I5M58_RS26700	5377721..5378719	+	999	WP_002885172.1	ribose ABC transporter permease	-
I5M58_RS26705	5378750..5379691	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I5M58_RS26710	5379766..5380773	+	1008	WP_194315625.1	carbohydrate kinase family protein	-
I5M58_RS26715	5380898..5381815	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I5M58_RS26720	5381821..5382579	-	759	WP_004151732.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I5M58_RS26725	5382665..5383393	-	729	WP_002885152.1	response regulator transcription factor	-
I5M58_RS26730	5383666..5385813	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
I5M58_RS26735	5386043..5386729	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T182781 WP_002885155.1 NZ_CP065460:c5381815-5380898 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T182781 NZ_CP086572:117824-117979 [Staphylococcus argenteus]
ATGTCTAAAGATAAAGATGCAAAATTAAATTATCACGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAGATGGAACAAATTTCAGATCAAAATGATCAAGAGAAGAGTACTGATGAAAAGAATAGCCATTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT182781 WP_004151732.1 NZ_CP065460:c5382579-5381821 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT182781 NZ_CP086572:117192-117791 [Staphylococcus argenteus]
ATGGCAATGAACTTTAAAGTATTTGACAACAGTCAACTTGTAGCAGAATATGCTGCAGATATTATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTGGATACAGACCAAGCACCAGTATTAGATGAACTAAAGAAAAATGTTG
AGAAACACGCTGTTGATTTTAGTCAAATAAATATTTTAGATTATGACAATAAAAAATCTTATTTTGAAGCATTAGGCGTG
CCAGCAAGTCAAATCTATCCAATTGCGTTTGAAAAAGATGCTATTGAATTTATCTCTGACAAAATTAAAACTAAAGAAAA
TAAAGGCAAACTAACATTACAAGTTGTTTCTATTGATGAGCATGGAAAATTAAATGTTAGTATCCGCCAAGGTTTAATGG
AAGCGAGAGAAATATTTTTAGTTGTGACAGGTGCTAATAAAAAGGAAGTTGTTGAAAAATTATACCAAGAAAATGGTAAA
ACAAGTTTCGAACCATCTGACTTAAAATCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTCAAAGCTTACTTTACATCTCGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A0H3GQB5