Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4507630..4508249 Replicon chromosome
Accession NZ_CP065460
Organism Klebsiella pneumoniae strain Gordon

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I5M58_RS22480 Protein ID WP_002892050.1
Coordinates 4508031..4508249 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I5M58_RS22475 Protein ID WP_002892066.1
Coordinates 4507630..4508004 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M58_RS22465 4502782..4503975 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I5M58_RS22470 4503998..4507144 + 3147 WP_194315611.1 multidrug efflux RND transporter permease subunit AcrB -
I5M58_RS22475 4507630..4508004 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I5M58_RS22480 4508031..4508249 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I5M58_RS22485 4508408..4508974 + 567 WP_117089397.1 maltose O-acetyltransferase -
I5M58_RS22490 4508946..4509086 - 141 WP_004147370.1 hypothetical protein -
I5M58_RS22495 4509107..4509577 + 471 WP_002892026.1 YlaC family protein -
I5M58_RS22500 4509552..4511003 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I5M58_RS22505 4511104..4511802 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
I5M58_RS22510 4511799..4511939 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I5M58_RS22515 4511939..4512202 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T182778 WP_002892050.1 NZ_CP065460:4508031-4508249 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T182778 NZ_CP086570:2672376-2672585 [Staphylococcus argenteus]
ATGGTACATCAAAACACAATATATACTGCAGGTATTGAAACTGAAGAACAAGTAAACCAGTTGACAGAACGTATATCAAA
CATGATAGGTGTGCATAAAGTGAATATTAATATCATTGATGGAGAAGTAGTTGTAGCATATGAAACACCCGCAAATTTAA
ATAGCATTGAAAAAGAAATTTATGATACAGGCTATAAAATTGTATATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT182778 WP_002892066.1 NZ_CP065460:4507630-4508004 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT182778 NZ_CP086570:2672071-2672364 [Staphylococcus argenteus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATTAAAACAAATCTTAAATCACGTTTAAATCGAATAGAAGGTCA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTTCTTACACAAATAAGAGCGACGCGTTCTG
CATTAAACAGTGTCGCAATAAAGTTATTAGAGCAACATATGAAAAGTTGTATTATGAATAAAGTAAATCAAGGTGCTCAA
GAAGAAGCGATGGAAGAGTTACTAGTTACTTTTCAAAAGTTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References