182739

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4019754..4020373 Replicon chromosome
Accession NZ_CP065453
Organism Klebsiella pneumoniae strain Beach Ranger

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I5M60_RS19730 Protein ID WP_002892050.1
Coordinates 4019754..4019972 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I5M60_RS19735 Protein ID WP_002892066.1
Coordinates 4019999..4020373 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M60_RS19695 4015801..4016064 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
I5M60_RS19700 4016064..4016204 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I5M60_RS19705 4016201..4016899 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
I5M60_RS19710 4017000..4018451 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I5M60_RS19715 4018426..4018896 - 471 WP_156649813.1 YlaC family protein -
I5M60_RS19720 4018917..4019057 + 141 WP_004147370.1 hypothetical protein -
I5M60_RS19725 4019029..4019595 - 567 WP_002892030.1 maltose O-acetyltransferase -
I5M60_RS19730 4019754..4019972 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I5M60_RS19735 4019999..4020373 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I5M60_RS19740 4020859..4024005 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I5M60_RS19745 4024028..4025221 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T182739 WP_002892050.1 NZ_CP065453:c4019972-4019754 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T182739 NZ_CP086558:1933179-1933523 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTGGAAGAATATGAAGTAGAGTTAGTTTTCGCTCCAATAAATAAGCGCGCATGTTACGA
GCCAGTCAAAAGAATAATTTTCGTAAATCAAAATTTATCTATCGAAGAACAAGAAGAGTCTATATTCCATGAGTTCAAAC
ATGTTGTTTCCCATTCGGATTACATGGAGTTATATAAAATCCCTTCTTTTAGAAATAAGATGGAAGCTGAGGCGGATCAT
CATATGTTTAAATGCCTTATTGAAAAACATGACGGGCAATTTAATTATTCTAATGTGATTACTCATTACAATTTAAAGAT
GGGACAAGAAACTTATTTAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT182739 WP_002892066.1 NZ_CP065453:c4020373-4019999 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT182739 NZ_CP086558:1932830-1933162 [Enterococcus faecalis]
ATGAACCTCTTGGAACGTATAAAAAAACTAGCAAAAGATAGAGATGTGTCTATTTATCAGCTTGAAGAAGAAATAAATAT
TGGACGAAATACTATTTATCAATGGAATAAGCGAACACCTTCTTCGGATAAACTTGAAGCTGTAGCCAATTATTTTAATG
TTTCTGTTGATTATTTATTAGGTCGTACTGAAAATCCAAACCAAGCTGGTGCTAAACCATCTGATGATTTAGATGAAGTA
TTAGACAATGTGATGAGTTTCGATGGTGAGCCTTTGGATGATCATGATCGGGAAGTTATTCGTGCTTATTTGAAAGGGAG
ATTCGGAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References