182731

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1877270..1877927 Replicon chromosome
Accession NZ_CP065453
Organism Klebsiella pneumoniae strain Beach Ranger

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I5M60_RS09265 Protein ID WP_002916310.1
Coordinates 1877270..1877680 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I5M60_RS09270 Protein ID WP_002916312.1
Coordinates 1877661..1877927 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M60_RS09245 1873270..1875003 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
I5M60_RS09250 1875009..1875722 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I5M60_RS09255 1875745..1876641 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I5M60_RS09260 1876742..1877263 + 522 WP_002916308.1 flavodoxin FldB -
I5M60_RS09265 1877270..1877680 - 411 WP_002916310.1 protein YgfX Toxin
I5M60_RS09270 1877661..1877927 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I5M60_RS09275 1878173..1879156 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I5M60_RS09280 1879307..1879966 - 660 WP_002916317.1 hemolysin III family protein -
I5M60_RS09285 1880130..1880441 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
I5M60_RS09290 1880491..1881219 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I5M60_RS09295 1881338..1882771 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T182731 WP_002916310.1 NZ_CP065453:c1877680-1877270 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T182731 NZ_CP086556:3759751-3760029 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT182731 WP_002916312.1 NZ_CP065453:c1877927-1877661 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT182731 NZ_CP086556:3759488-3759748 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References