Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2709229..2709848 Replicon chromosome
Accession NZ_CP065447
Organism Klebsiella pneumoniae strain Ocean Ranger

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I5M61_RS13375 Protein ID WP_002892050.1
Coordinates 2709630..2709848 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I5M61_RS13370 Protein ID WP_002892066.1
Coordinates 2709229..2709603 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M61_RS13360 2704381..2705574 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I5M61_RS13365 2705597..2708743 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I5M61_RS13370 2709229..2709603 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I5M61_RS13375 2709630..2709848 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I5M61_RS13380 2710007..2710573 + 567 WP_002892030.1 maltose O-acetyltransferase -
I5M61_RS13385 2710545..2710685 - 141 WP_004147370.1 hypothetical protein -
I5M61_RS13390 2710706..2711176 + 471 WP_002892026.1 YlaC family protein -
I5M61_RS13395 2711151..2712602 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I5M61_RS13400 2712703..2713401 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
I5M61_RS13405 2713398..2713538 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I5M61_RS13410 2713538..2713801 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T182712 WP_002892050.1 NZ_CP065447:2709630-2709848 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T182712 NZ_CP086546:c42272-42120 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT182712 WP_002892066.1 NZ_CP065447:2709229-2709603 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT182712 NZ_CP086546:42324-42384 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References