Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1019455..1019971 Replicon chromosome
Accession NZ_CP065438
Organism Klebsiella pneumoniae strain Mrs. Puff

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag I5M55_RS04915 Protein ID WP_002886902.1
Coordinates 1019687..1019971 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I5M55_RS04910 Protein ID WP_002886901.1
Coordinates 1019455..1019697 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5M55_RS04895 1015484..1016224 + 741 WP_002886899.1 KDGP aldolase family protein -
I5M55_RS04900 1016290..1017444 + 1155 WP_002886900.1 lactonase family protein -
I5M55_RS04905 1017467..1019377 + 1911 WP_004152270.1 BglG family transcription antiterminator -
I5M55_RS04910 1019455..1019697 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I5M55_RS04915 1019687..1019971 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5M55_RS04920 1019975..1020439 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I5M55_RS04925 1020680..1022818 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
I5M55_RS04930 1023175..1023918 - 744 WP_151370208.1 MurR/RpiR family transcriptional regulator -
I5M55_RS04935 1023921..1024094 - 174 WP_002886906.1 hypothetical protein -
I5M55_RS04940 1024179..1024487 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T182640 WP_002886902.1 NZ_CP065438:1019687-1019971 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T182640 NZ_CP086520:2648731-2648838 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT182640 WP_002886901.1 NZ_CP065438:1019455-1019697 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT182640 NZ_CP086520:c2648678-2648617 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References