Detailed information of TA system TA182629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3606459..3608140
• Replicon: chromosome
• Accession: NZ_CP065436
• Organism: Klebsiella pneumoniae strain Dirty Dan

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: I6Z21_RS17710
• Protein ID: WP_015959269.1
• Coordinates: 3606459..3607334 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A6G4MDP5
• Locus tag: I6Z21_RS17715
• Protein ID: WP_065801074.1
• Coordinates: 3607382..3608140 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6Z21_RS17690	3601765..3603285	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
I6Z21_RS17695	3603282..3604280	+	999	WP_002885172.1	ribose ABC transporter permease	-
I6Z21_RS17700	3604311..3605252	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I6Z21_RS17705	3605327..3606334	+	1008	WP_194428825.1	carbohydrate kinase family protein	-
I6Z21_RS17710	3606459..3607334	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6Z21_RS17715	3607382..3608140	-	759	WP_065801074.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I6Z21_RS17720	3608226..3608954	-	729	WP_023288135.1	response regulator transcription factor	-
I6Z21_RS17725	3609227..3611374	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
I6Z21_RS17730	3611604..3612290	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T182629 WP_015959269.1 NZ_CP065436:c3607334-3606459 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T182629 NZ_CP086520:316247-316477 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28576.98 Da
• Isoelectric Point: 10.0870

>AT182629 WP_065801074.1 NZ_CP065436:c3608140-3607382 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARVGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT182629 NZ_CP086520:316474-316833 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A0A6G4MDP5