Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3446285..3446801 Replicon chromosome
Accession NZ_CP065436
Organism Klebsiella pneumoniae strain Dirty Dan

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag I6Z21_RS16905 Protein ID WP_009486548.1
Coordinates 3446285..3446569 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A331AB37
Locus tag I6Z21_RS16910 Protein ID WP_019704689.1
Coordinates 3446559..3446801 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6Z21_RS16880 3441768..3442076 - 309 WP_194428815.1 PTS sugar transporter subunit IIB -
I6Z21_RS16885 3442161..3442334 + 174 WP_032416265.1 hypothetical protein -
I6Z21_RS16890 3442337..3443080 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6Z21_RS16895 3443437..3445575 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6Z21_RS16900 3445817..3446281 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6Z21_RS16905 3446285..3446569 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6Z21_RS16910 3446559..3446801 - 243 WP_019704689.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6Z21_RS16915 3446879..3448789 - 1911 WP_194428816.1 BglG family transcription antiterminator -
I6Z21_RS16920 3448812..3449966 - 1155 WP_194428817.1 lactonase family protein -
I6Z21_RS16925 3450033..3450773 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T182628 WP_009486548.1 NZ_CP065436:c3446569-3446285 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T182628 NZ_CP086516:15031-15282 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATCACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGAAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9044.56 Da        Isoelectric Point: 8.5313

>AT182628 WP_019704689.1 NZ_CP065436:c3446801-3446559 [Klebsiella pneumoniae]
MATLNVRLDDKLKKQAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT182628 NZ_CP086516:15269-15496 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A331AB37

References