Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 3341318..3342128 Replicon chromosome
Accession NZ_CP065436
Organism Klebsiella pneumoniae strain Dirty Dan

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag I6Z21_RS16430 Protein ID WP_004178461.1
Coordinates 3341318..3341851 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag I6Z21_RS16435 Protein ID WP_002887278.1
Coordinates 3341862..3342128 (-) Length 89 a.a.

Genomic Context


I6Z21_RS16425I6Z21_RS16450I6Z21_RS16455I6Z21_RS16430I6Z21_RS16435I6Z21_RS16440I6Z21_RS16445
Location: 3340149..3341270 (1122 bp)
Type: Others
Protein ID: WP_009309849.1
Location: 3344509..3345894 (1386 bp)
Type: Others
Protein ID: WP_040238382.1
Location: 3345912..3346256 (345 bp)
Type: Others
Protein ID: WP_002887266.1
Location: 3341318..3341851 (534 bp)
Type: Toxin
Protein ID: WP_004178461.1
Location: 3341862..3342128 (267 bp)
Type: Antitoxin
Protein ID: WP_002887278.1
Location: 3342231..3343664 (1434 bp)
Type: Others
Protein ID: WP_141408345.1
Location: 3343654..3344337 (684 bp)
Type: Others
Protein ID: WP_002887273.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6Z21_RS164253340149..3341270+1122WP_009309849.1cupin domain-containing protein-
I6Z21_RS164303341318..3341851-534WP_004178461.1GNAT family N-acetyltransferaseToxin
I6Z21_RS164353341862..3342128-267WP_002887278.1DUF1778 domain-containing proteinAntitoxin
I6Z21_RS164403342231..3343664-1434WP_141408345.1Cu(+)/Ag(+) sensor histidine kinase-
I6Z21_RS164453343654..3344337-684WP_002887273.1copper response regulator transcription factor CusR-
I6Z21_RS164503344509..3345894+1386WP_040238382.1efflux transporter outer membrane subunit-
I6Z21_RS164553345912..3346256+345WP_002887266.1cation efflux system protein CusF-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(91-151)

Antitoxin

(2-86)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T182627 WP_004178461.1 NZ_CP065436:c3341851-3341318 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T182627 NZ_CP086515:9618-9878 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACATTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAATCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTATTTTTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT182627 WP_002887278.1 NZ_CP065436:c3342128-3341862 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT182627 NZ_CP086515:9868-10119 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A060VJ83


Antitoxin

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Source
ID
Structure
PDB5ZGN
AlphaFold DBA0A0H3GLZ1

References