Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
Location | 3341318..3342128 | Replicon | chromosome |
Accession | NZ_CP065436 | ||
Organism | Klebsiella pneumoniae strain Dirty Dan |
Toxin (Protein)
Gene name | KacT | Uniprot ID | A0A060VJ83 |
Locus tag | I6Z21_RS16430 | Protein ID | WP_004178461.1 |
Coordinates | 3341318..3341851 (-) | Length | 178 a.a. |
Antitoxin (Protein)
Gene name | KacA | Uniprot ID | J2E9Q7 |
Locus tag | I6Z21_RS16435 | Protein ID | WP_002887278.1 |
Coordinates | 3341862..3342128 (-) | Length | 89 a.a. |
Genomic Context
Location: 3340149..3341270 (1122 bp)
Type: Others
Protein ID: WP_009309849.1
Type: Others
Protein ID: WP_009309849.1
Location: 3344509..3345894 (1386 bp)
Type: Others
Protein ID: WP_040238382.1
Type: Others
Protein ID: WP_040238382.1
Location: 3345912..3346256 (345 bp)
Type: Others
Protein ID: WP_002887266.1
Type: Others
Protein ID: WP_002887266.1
Location: 3341318..3341851 (534 bp)
Type: Toxin
Protein ID: WP_004178461.1
Type: Toxin
Protein ID: WP_004178461.1
Location: 3341862..3342128 (267 bp)
Type: Antitoxin
Protein ID: WP_002887278.1
Type: Antitoxin
Protein ID: WP_002887278.1
Location: 3342231..3343664 (1434 bp)
Type: Others
Protein ID: WP_141408345.1
Type: Others
Protein ID: WP_141408345.1
Location: 3343654..3344337 (684 bp)
Type: Others
Protein ID: WP_002887273.1
Type: Others
Protein ID: WP_002887273.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6Z21_RS16425 | 3340149..3341270 | + | 1122 | WP_009309849.1 | cupin domain-containing protein | - |
I6Z21_RS16430 | 3341318..3341851 | - | 534 | WP_004178461.1 | GNAT family N-acetyltransferase | Toxin |
I6Z21_RS16435 | 3341862..3342128 | - | 267 | WP_002887278.1 | DUF1778 domain-containing protein | Antitoxin |
I6Z21_RS16440 | 3342231..3343664 | - | 1434 | WP_141408345.1 | Cu(+)/Ag(+) sensor histidine kinase | - |
I6Z21_RS16445 | 3343654..3344337 | - | 684 | WP_002887273.1 | copper response regulator transcription factor CusR | - |
I6Z21_RS16450 | 3344509..3345894 | + | 1386 | WP_040238382.1 | efflux transporter outer membrane subunit | - |
I6Z21_RS16455 | 3345912..3346256 | + | 345 | WP_002887266.1 | cation efflux system protein CusF | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19810.65 Da Isoelectric Point: 5.2614
>T182627 WP_004178461.1 NZ_CP065436:c3341851-3341318 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
Download Length: 534 bp
>T182627 NZ_CP086515:9618-9878 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACATTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAATCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTATTTTTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACATTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAATCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTATTTTTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9996.46 Da Isoelectric Point: 10.1757
>AT182627 WP_002887278.1 NZ_CP065436:c3342128-3341862 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR
Download Length: 267 bp
>AT182627 NZ_CP086515:9868-10119 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A060VJ83 |
Antitoxin
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Source | ID | Structure |
---|---|---|
PDB | 5ZGN | |
AlphaFold DB | A0A0H3GLZ1 |