Detailed information of TA system TA182624

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1388839..1390427
• Replicon: chromosome
• Accession: NZ_CP065436
• Organism: Klebsiella pneumoniae strain Dirty Dan

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6Z21_RS06810
• Protein ID: WP_049109073.1
• Coordinates: 1388839..1390161 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: I6Z21_RS06815
• Protein ID: WP_002904790.1
• Coordinates: 1390161..1390427 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6Z21_RS06795	1383895..1386396	+	2502	WP_004190161.1	fimbrial biogenesis outer membrane usher protein	-
I6Z21_RS06800	1386384..1387388	+	1005	WP_004190163.1	type 1 fimbrial protein	-
I6Z21_RS06805	1387530..1388822	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
I6Z21_RS06810	1388839..1390161	-	1323	WP_049109073.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6Z21_RS06815	1390161..1390427	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6Z21_RS06820	1390814..1391140	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
I6Z21_RS06825	1391137..1391637	-	501	WP_186944391.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
I6Z21_RS06830	1391615..1392994	-	1380	WP_004199850.1	purine permease	-
I6Z21_RS06835	1393340..1394494	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
I6Z21_RS06840	1394475..1395398	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49115.40 Da
• Isoelectric Point: 7.5357

>T182624 WP_049109073.1 NZ_CP065436:c1390161-1388839 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPAGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T182624 NZ_CP086513:c48869-48489 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACGGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCTCCCGTGCTGGTGGAACTTGCGGTGGGGGCCGCAACAGG
TGAAATCCCCGTATCTTCAGTAGCGGAAAAACTACGTGAATTATTTGGTTCCAATATTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT182624 WP_002904790.1 NZ_CP065436:c1390427-1390161 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT182624 NZ_CP086513:c49090-48869 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGAGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTTGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8