Detailed information of TA system TA182613

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 449556..450209
• Replicon: chromosome
• Accession: NZ_CP065432
• Organism: Acinetobacter baumannii strain ATCC 17961

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I5593_RS02175
• Protein ID: WP_000607072.1
• Coordinates: 449820..450209 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: I5593_RS02170
• Protein ID: WP_001288210.1
• Coordinates: 449556..449813 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5593_RS02150	445072..446079	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
I5593_RS02155	446098..446475	+	378	WP_001216380.1	50S ribosomal protein L17	-
I5593_RS02160	446657..448147	+	1491	WP_000415138.1	NAD(P)/FAD-dependent oxidoreductase	-
I5593_RS02165	448196..449368	-	1173	WP_001190549.1	acyl-CoA dehydrogenase family protein	-
I5593_RS02170	449556..449813	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
I5593_RS02175	449820..450209	+	390	WP_000607072.1	membrane protein	Toxin
I5593_RS02180	450979..452064	+	1086	WP_000049106.1	hypothetical protein	-
I5593_RS02185	452142..452708	+	567	WP_000651536.1	rhombosortase	-
I5593_RS02190	452896..455091	+	2196	WP_001158907.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15663.97 Da
• Isoelectric Point: 10.3890

>T182613 WP_000607072.1 NZ_CP065432:449820-450209 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLVDWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T182613 NZ_CP086510:3573991-3574209 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT182613 WP_001288210.1 NZ_CP065432:449556-449813 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT182613 NZ_CP086510:3573591-3573965 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7