Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1964730..1965336 Replicon chromosome
Accession NZ_CP065431
Organism Streptococcus suis strain YP20190405

Toxin (Protein)


Gene name parE Uniprot ID A0A0Z8ZB64
Locus tag I5W22_RS09645 Protein ID WP_012775364.1
Coordinates 1964730..1965059 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID D5AKB4
Locus tag I5W22_RS09650 Protein ID WP_012028535.1
Coordinates 1965049..1965336 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5W22_RS09605 1959761..1960249 - 489 WP_024392286.1 hypothetical protein -
I5W22_RS09610 1960327..1960911 - 585 WP_197308492.1 CPBP family intramembrane metalloprotease -
I5W22_RS09615 1960914..1961147 - 234 WP_001005709.1 hypothetical protein -
I5W22_RS09620 1961156..1961539 - 384 WP_197308493.1 hypothetical protein -
I5W22_RS09625 1961550..1961978 - 429 WP_197308494.1 hypothetical protein -
I5W22_RS09630 1961962..1963317 - 1356 WP_197308495.1 DNA (cytosine-5-)-methyltransferase -
I5W22_RS09635 1963467..1964270 - 804 WP_197308496.1 replication initiator protein A -
I5W22_RS09640 1964267..1964440 - 174 WP_197308497.1 hypothetical protein -
I5W22_RS09645 1964730..1965059 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5W22_RS09650 1965049..1965336 - 288 WP_012028535.1 hypothetical protein Antitoxin
I5W22_RS09655 1965434..1965802 - 369 WP_012775453.1 hypothetical protein -
I5W22_RS09660 1965795..1966364 - 570 WP_012775366.1 ribonuclease M5 -
I5W22_RS09665 1966348..1967130 - 783 WP_012028536.1 TatD family hydrolase -
I5W22_RS09670 1967237..1967374 - 138 WP_002939016.1 50S ribosomal protein L34 -
I5W22_RS09675 1967542..1968537 - 996 WP_012775367.1 protein jag -
I5W22_RS09680 1968557..1969369 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
I5W22_RS09685 1969353..1969712 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12562.52 Da        Isoelectric Point: 7.1991

>T182612 WP_012775364.1 NZ_CP065431:c1965059-1964730 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVVGKD
YIALYRVVKNEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T182612 NZ_CP086510:2755701-2755808 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.43 Da        Isoelectric Point: 4.3464

>AT182612 WP_012028535.1 NZ_CP065431:c1965336-1965049 [Streptococcus suis]
MITINKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GHGISLESVKEKYGI

Download         Length: 288 bp

>AT182612 NZ_CP086510:c2755654-2755588 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8ZB64

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9A6F4

References