Detailed information of TA system TA182611

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1949661..1951093
• Replicon: chromosome
• Accession: NZ_CP065431
• Organism: Streptococcus suis strain YP20190405

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: I5W22_RS09570
• Protein ID: WP_105208271.1
• Coordinates: 1950248..1951093 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: I5W22_RS09565
• Protein ID: WP_105208272.1
• Coordinates: 1949661..1950251 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5W22_RS09565	1949661..1950251	+	591	WP_105208272.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
I5W22_RS09570	1950248..1951093	+	846	WP_105208271.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I5W22_RS09575	1951180..1953957	-	2778	WP_197308488.1	CHAP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B) / tet(O)	-	1887698..1961899	74201

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32522.35 Da
• Isoelectric Point: 5.4360

>T182611 WP_105208271.1 NZ_CP065431:1950248-1951093 [Streptococcus suis]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEMILKKLSQSAYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQMTLSED
TVKQQLKEILVDSEEGISFVIQSIKAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYNYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLRNACQRTFSYRETELDFVKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMISLITIIISTDLD

Nucleotide

• Length: 846 bp

>T182611 NZ_CP086510:2755166-2755273 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23297.80 Da
• Isoelectric Point: 7.3722

>AT182611 WP_105208272.1 NZ_CP065431:1949661-1950251 [Streptococcus suis]
MSKKEILLEFIENHNGIITYRDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKEYSELGITLVKTPMGNEVRVHDFERIICDFVIHREKIDTELFVKT
LQHYGNYPKKNLTKLYEYATKMNTLDKVKQTLEVLV

Nucleotide

• Length: 591 bp

>AT182611 NZ_CP086510:c2755119-2755053 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT