182610

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1928063..1928606 Replicon chromosome
Accession NZ_CP065431
Organism Streptococcus suis strain YP20190405

Toxin (Protein)


Gene name zeta Uniprot ID A0A1X9I2P4
Locus tag I5W22_RS09470 Protein ID WP_002943355.1
Coordinates 1928063..1928332 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag I5W22_RS09475 Protein ID WP_002326825.1
Coordinates 1928334..1928606 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5W22_RS09425 1923155..1923451 - 297 WP_044758818.1 hypothetical protein -
I5W22_RS09430 1923501..1923890 - 390 WP_002943340.1 hypothetical protein -
I5W22_RS09435 1923887..1924114 - 228 WP_002943342.1 hypothetical protein -
I5W22_RS09440 1924168..1925244 - 1077 WP_044758819.1 toprim domain-containing protein -
I5W22_RS09445 1925284..1925922 - 639 WP_050887020.1 hypothetical protein -
I5W22_RS09450 1926018..1926308 - 291 WP_105152240.1 hypothetical protein -
I5W22_RS09455 1926322..1926621 - 300 WP_002943350.1 hypothetical protein -
I5W22_RS09460 1926692..1927651 - 960 Protein_1825 hypothetical protein -
I5W22_RS09465 1927644..1927965 - 322 Protein_1826 DUF4368 domain-containing protein -
I5W22_RS09470 1928063..1928332 - 270 WP_002943355.1 zeta toxin family protein Toxin
I5W22_RS09475 1928334..1928606 - 273 WP_002326825.1 antitoxin Antitoxin
I5W22_RS09480 1928624..1928833 - 210 WP_000527318.1 peptide-binding protein -
I5W22_RS09485 1928917..1929813 - 897 WP_002326827.1 ParA family protein -
I5W22_RS09490 1929916..1930176 - 261 Protein_1831 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
I5W22_RS09495 1930346..1931083 - 738 WP_001038795.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
I5W22_RS09500 1931208..1931291 - 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
I5W22_RS09505 1931340..1931579 - 240 WP_000635249.1 peptide-binding protein -
I5W22_RS09510 1931671..1932771 - 1101 Protein_1835 recombinase family protein -
I5W22_RS09515 1932825..1933016 - 192 WP_000503424.1 hypothetical protein -
I5W22_RS09520 1933087..1933317 - 231 WP_000659121.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O) - 1887698..1961899 74201
- flank IS/Tn erm(B) / tet(O) - 1930346..1937147 6801


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-75)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 9999.08 Da        Isoelectric Point: 8.7696

>T182610 WP_002943355.1 NZ_CP065431:c1928332-1928063 [Streptococcus suis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS

Download         Length: 270 bp

>T182610 NZ_CP086510:c2542204-2542028 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT182610 WP_002326825.1 NZ_CP065431:c1928606-1928334 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT182610 NZ_CP086510:c2541982-2541566 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9I2P4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References