Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 936384..936927 Replicon chromosome
Accession NZ_CP065431
Organism Streptococcus suis strain YP20190405

Toxin (Protein)


Gene name zeta Uniprot ID A0A1X9I2P4
Locus tag I5W22_RS04615 Protein ID WP_002943355.1
Coordinates 936384..936653 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag I5W22_RS04620 Protein ID WP_002326825.1
Coordinates 936655..936927 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5W22_RS04570 931476..931772 - 297 WP_044758818.1 hypothetical protein -
I5W22_RS04575 931822..932211 - 390 WP_002943340.1 hypothetical protein -
I5W22_RS04580 932208..932435 - 228 WP_002943342.1 hypothetical protein -
I5W22_RS04585 932489..933565 - 1077 WP_044758819.1 toprim domain-containing protein -
I5W22_RS04590 933605..934243 - 639 WP_050887020.1 hypothetical protein -
I5W22_RS04595 934339..934629 - 291 WP_105152240.1 hypothetical protein -
I5W22_RS04600 934643..934942 - 300 WP_002943350.1 hypothetical protein -
I5W22_RS04605 935013..935972 - 960 Protein_860 hypothetical protein -
I5W22_RS04610 935965..936286 - 322 Protein_861 DUF4368 domain-containing protein -
I5W22_RS04615 936384..936653 - 270 WP_002943355.1 zeta toxin family protein Toxin
I5W22_RS04620 936655..936927 - 273 WP_002326825.1 antitoxin Antitoxin
I5W22_RS04625 936945..937154 - 210 WP_000527318.1 peptide-binding protein -
I5W22_RS04630 937238..938134 - 897 WP_002326827.1 ParA family protein -
I5W22_RS04635 938237..938497 - 261 Protein_866 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
I5W22_RS04640 938667..939404 - 738 WP_001038795.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
I5W22_RS04645 939529..939612 - 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
I5W22_RS04650 939661..939900 - 240 WP_000635249.1 peptide-binding protein -
I5W22_RS04655 939992..941092 - 1101 Protein_870 recombinase family protein -
I5W22_RS04660 941146..941337 - 192 WP_000503424.1 hypothetical protein -
I5W22_RS04665 941408..941638 - 231 WP_000659121.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O) - 812559..971979 159420
- flank IS/Tn erm(B) / tet(O) - 938667..945468 6801


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-75)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 9999.08 Da        Isoelectric Point: 8.7696

>T182606 WP_002943355.1 NZ_CP065431:c936653-936384 [Streptococcus suis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS

Download         Length: 270 bp

>T182606 NZ_CP086510:1907829-1908083 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT182606 WP_002326825.1 NZ_CP065431:c936927-936655 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT182606 NZ_CP086510:1907581-1907832 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9I2P4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References