Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 859363..859855 Replicon chromosome
Accession NZ_CP065431
Organism Streptococcus suis strain YP20190405

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag I5W22_RS04205 Protein ID WP_011922404.1
Coordinates 859363..859620 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag I5W22_RS04210 Protein ID WP_012775104.1
Coordinates 859604..859855 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5W22_RS04185 854997..856067 + 1071 WP_012775436.1 tyrosine recombinase XerS -
I5W22_RS04190 856137..857645 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
I5W22_RS04195 857721..858662 - 942 WP_012775102.1 sensor histidine kinase -
I5W22_RS04200 858659..859324 - 666 WP_012775103.1 response regulator transcription factor -
I5W22_RS04205 859363..859620 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5W22_RS04210 859604..859855 - 252 WP_012775104.1 hypothetical protein Antitoxin
I5W22_RS04215 859947..861917 - 1971 WP_012775105.1 FtsX-like permease family protein -
I5W22_RS04220 861918..862670 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
I5W22_RS04225 862806..863540 - 735 WP_011922410.1 ABC transporter permease -
I5W22_RS04230 863542..864288 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(O) - 812559..971979 159420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T182605 WP_011922404.1 NZ_CP065431:c859620-859363 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T182605 NZ_CP086510:1907581-1907832 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT182605 WP_012775104.1 NZ_CP065431:c859855-859604 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT182605 NZ_CP086510:1907829-1908083 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References