Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 597096..597582 | Replicon | chromosome |
Accession | NZ_CP065431 | ||
Organism | Streptococcus suis strain YP20190405 |
Toxin (Protein)
Gene name | relE | Uniprot ID | D5AGV2 |
Locus tag | I5W22_RS02960 | Protein ID | WP_011922754.1 |
Coordinates | 597313..597582 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | D5AGV1 |
Locus tag | I5W22_RS02955 | Protein ID | WP_002938604.1 |
Coordinates | 597096..597323 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I5W22_RS02930 | 592139..592588 | - | 450 | WP_009909619.1 | MarR family transcriptional regulator | - |
I5W22_RS02935 | 592882..593729 | + | 848 | WP_087892711.1 | IS630 family transposase | - |
I5W22_RS02940 | 593788..594285 | + | 498 | WP_011922751.1 | DUF5590 domain-containing protein | - |
I5W22_RS02945 | 594282..595463 | + | 1182 | WP_011922154.1 | pyridoxal phosphate-dependent aminotransferase | - |
I5W22_RS02950 | 595478..596824 | + | 1347 | WP_011922752.1 | asparagine--tRNA ligase | - |
I5W22_RS02955 | 597096..597323 | + | 228 | WP_002938604.1 | hypothetical protein | Antitoxin |
I5W22_RS02960 | 597313..597582 | + | 270 | WP_011922754.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
I5W22_RS02965 | 597988..599307 | + | 1320 | WP_012775027.1 | MATE family efflux transporter | - |
I5W22_RS02970 | 599358..599735 | + | 378 | WP_002937263.1 | RidA family protein | - |
I5W22_RS02975 | 599757..600644 | + | 888 | WP_011922160.1 | RNase adapter RapZ | - |
I5W22_RS02980 | 600641..601615 | + | 975 | WP_002937257.1 | YvcK family protein | - |
I5W22_RS02985 | 601612..602529 | + | 918 | WP_002937252.1 | DNA-binding protein WhiA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10437.49 Da Isoelectric Point: 10.3916
>T182604 WP_011922754.1 NZ_CP065431:597313-597582 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK
Download Length: 270 bp
>T182604 NZ_CP086510:1077622-1077957 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 76 a.a. Molecular weight: 8450.51 Da Isoelectric Point: 4.1589
>AT182604 WP_002938604.1 NZ_CP065431:597096-597323 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL
Download Length: 228 bp
>AT182604 NZ_CP086510:1077374-1077622 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A126UKS2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A140EXF0 |