Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2298373..2298979 Replicon chromosome
Accession NZ_CP065430
Organism Streptococcus suis strain YZDH1

Toxin (Protein)


Gene name parE Uniprot ID A0A123TJ26
Locus tag I5V48_RS10915 Protein ID WP_043025159.1
Coordinates 2298373..2298702 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A075SKR5
Locus tag I5V48_RS10920 Protein ID WP_024381177.1
Coordinates 2298692..2298979 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5V48_RS10895 2294922..2295454 - 533 Protein_2110 IS200/IS605 family transposase -
I5V48_RS10900 2295646..2296518 - 873 WP_043025154.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
I5V48_RS10905 2296696..2297865 - 1170 WP_052496980.1 hypothetical protein -
I5V48_RS10910 2297882..2298265 - 384 WP_043025156.1 DUF2513 domain-containing protein -
I5V48_RS10915 2298373..2298702 - 330 WP_043025159.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5V48_RS10920 2298692..2298979 - 288 WP_024381177.1 hypothetical protein Antitoxin
I5V48_RS10925 2299077..2299445 - 369 WP_043025162.1 hypothetical protein -
I5V48_RS10930 2299438..2300007 - 570 WP_043025164.1 ribonuclease M5 -
I5V48_RS10935 2299991..2300773 - 783 WP_079395255.1 TatD family hydrolase -
I5V48_RS10940 2300877..2301014 - 138 WP_043025166.1 50S ribosomal protein L34 -
I5V48_RS10945 2301182..2302177 - 996 WP_002940330.1 protein jag -
I5V48_RS10950 2302197..2303009 - 813 WP_002940331.1 YidC/Oxa1 family membrane protein insertase -
I5V48_RS10955 2302993..2303352 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2295102..2295281 179


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-96)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12585.43 Da        Isoelectric Point: 6.2346

>T182603 WP_043025159.1 NZ_CP065430:c2298702-2298373 [Streptococcus suis]
MEFESHSVILAPAVEQELAAIYAYFSEQFSEEIAKRRIGMIVEALESLRIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVENEVRVGHFFATKSDYVKLLK

Download         Length: 330 bp

>T182603 NZ_CP086510:933272-933679 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10897.49 Da        Isoelectric Point: 4.3472

>AT182603 WP_024381177.1 NZ_CP065430:c2298979-2298692 [Streptococcus suis]
MITIKKDAQVNFKTDSRLLEKAKEVFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GQGISLESVKEKYGI

Download         Length: 288 bp

>AT182603 NZ_CP086510:933025-933291 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A123TJ26

Antitoxin

Source ID Structure
AlphaFold DB A0A075SKR5

References