Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1561785..1562388 Replicon chromosome
Accession NZ_CP065430
Organism Streptococcus suis strain YZDH1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0N0DNR4
Locus tag I5V48_RS07505 Protein ID WP_002941795.1
Coordinates 1561785..1561976 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7T1L8L6
Locus tag I5V48_RS07510 Protein ID WP_061756373.1
Coordinates 1562011..1562388 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5V48_RS07495 1560705..1561364 - 660 WP_079267551.1 site-specific integrase -
I5V48_RS07500 1561341..1561616 + 276 Protein_1448 ArpU family transcriptional regulator -
I5V48_RS07505 1561785..1561976 + 192 WP_002941795.1 type II toxin-antitoxin system HicA family toxin Toxin
I5V48_RS07510 1562011..1562388 + 378 WP_061756373.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I5V48_RS07515 1562710..1564977 - 2268 Protein_1451 glycogen/starch/alpha-glucan family phosphorylase -
I5V48_RS07520 1565153..1565866 - 714 WP_043026422.1 purine-nucleoside phosphorylase -
I5V48_RS07525 1565899..1566708 - 810 WP_197315012.1 purine-nucleoside phosphorylase -
I5V48_RS07530 1566720..1567076 - 357 WP_043026425.1 ArsC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-106)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6989.26 Da        Isoelectric Point: 10.5552

>T182602 WP_002941795.1 NZ_CP065430:1561785-1561976 [Streptococcus suis]
MPLTGKEMAKLAEANGWKEIRVNGSHHHFKKEGFSKIVTIPVHGNKDLGKGLEKKILKDLGLL

Download         Length: 192 bp

>T182602 NZ_CP086510:c796684-796310 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14209.05 Da        Isoelectric Point: 4.2621

>AT182602 WP_061756373.1 NZ_CP065430:1562011-1562388 [Streptococcus suis]
MLKSYPAIFHKDEQGYWVEFPEFSGGTQGDNLEEAMYNAREFLESSIALYIDEGMELPKVSDIKELSAPDGFVSMIQADP
TPYIKNNKAIRKNVTVPEWLTKLADREGLNYSEILTTALETRLQV

Download         Length: 378 bp

>AT182602 NZ_CP086510:c797142-796774 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0DNR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1L8L6

References