Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1302843..1303338 Replicon chromosome
Accession NZ_CP065430
Organism Streptococcus suis strain YZDH1

Toxin (Protein)


Gene name relE Uniprot ID A0A116MI42
Locus tag I5V48_RS06370 Protein ID WP_032510493.1
Coordinates 1303072..1303338 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A123SEG2
Locus tag I5V48_RS06365 Protein ID WP_015646833.1
Coordinates 1302843..1303082 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5V48_RS06340 1297918..1299210 - 1293 WP_197314991.1 IS110 family transposase -
I5V48_RS06345 1299500..1299640 + 141 WP_032500004.1 hypothetical protein -
I5V48_RS06350 1299653..1300036 + 384 WP_043025610.1 NisI/SpaI family lantibiotic immunity lipoprotein -
I5V48_RS06355 1300053..1300805 + 753 WP_029173099.1 ABC transporter ATP-binding protein -
I5V48_RS06360 1300806..1302752 + 1947 WP_043025612.1 FtsX-like permease family protein -
I5V48_RS06365 1302843..1303082 + 240 WP_015646833.1 hypothetical protein Antitoxin
I5V48_RS06370 1303072..1303338 + 267 WP_032510493.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I5V48_RS06375 1303380..1304045 + 666 WP_043025615.1 response regulator transcription factor -
I5V48_RS06380 1304042..1304983 + 942 WP_043025617.1 sensor histidine kinase -
I5V48_RS06385 1305343..1306146 + 804 Protein_1230 transposase -
I5V48_RS06390 1306334..1307483 - 1150 Protein_1231 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / erm(B) nanB 1161951..1343152 181201
- flank IS/Tn - - 1297918..1299120 1202
- flank IS/Tn - - 1306334..1307401 1067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10241.95 Da        Isoelectric Point: 10.4518

>T182601 WP_032510493.1 NZ_CP065430:1303072-1303338 [Streptococcus suis]
MSYKVILSAKAQKQIRKLDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T182601 NZ_CP086510:721529-721825 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8879.09 Da        Isoelectric Point: 3.7832

>AT182601 WP_015646833.1 NZ_CP065430:1302843-1303082 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT182601 NZ_CP086510:721827-722222 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A116MI42

Antitoxin

Source ID Structure
AlphaFold DB A0A123SEG2

References