Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1199376..1199919 Replicon chromosome
Accession NZ_CP065430
Organism Streptococcus suis strain YZDH1

Toxin (Protein)


Gene name zeta Uniprot ID A0A1X9I2P4
Locus tag I5V48_RS05855 Protein ID WP_002943355.1
Coordinates 1199650..1199919 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag I5V48_RS05850 Protein ID WP_002326825.1
Coordinates 1199376..1199648 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5V48_RS05805 1194665..1194895 + 231 WP_000659121.1 hypothetical protein -
I5V48_RS05810 1194966..1195157 + 192 WP_000503424.1 hypothetical protein -
I5V48_RS05815 1195211..1196311 + 1101 Protein_1116 recombinase family protein -
I5V48_RS05820 1196403..1196642 + 240 WP_000635249.1 peptide-binding protein -
I5V48_RS05825 1196691..1196774 + 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
I5V48_RS05830 1196899..1197636 + 738 WP_001038795.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
I5V48_RS05835 1197806..1198066 + 261 Protein_1120 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
I5V48_RS05840 1198169..1199065 + 897 WP_002326827.1 ParA family protein -
I5V48_RS05845 1199149..1199358 + 210 WP_000527318.1 peptide-binding protein -
I5V48_RS05850 1199376..1199648 + 273 WP_002326825.1 antitoxin Antitoxin
I5V48_RS05855 1199650..1199919 + 270 WP_002943355.1 zeta toxin family protein Toxin
I5V48_RS05860 1200017..1200338 + 322 Protein_1125 DUF4368 domain-containing protein -
I5V48_RS05865 1200331..1201290 + 960 Protein_1126 hypothetical protein -
I5V48_RS05870 1201361..1201660 + 300 WP_002943350.1 hypothetical protein -
I5V48_RS05875 1201674..1201964 + 291 WP_105152240.1 hypothetical protein -
I5V48_RS05880 1202060..1202698 + 639 WP_050887020.1 hypothetical protein -
I5V48_RS05885 1202738..1203814 + 1077 WP_044758819.1 toprim domain-containing protein -
I5V48_RS05890 1203868..1204095 + 228 WP_002943342.1 hypothetical protein -
I5V48_RS05895 1204092..1204481 + 390 WP_002943340.1 hypothetical protein -
I5V48_RS05900 1204531..1204827 + 297 WP_044758818.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / erm(B) nanB 1161951..1343152 181201
- flank IS/Tn tet(O) / erm(B) - 1190835..1197636 6801


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-75)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 9999.08 Da        Isoelectric Point: 8.7696

>T182600 WP_002943355.1 NZ_CP065430:1199650-1199919 [Streptococcus suis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS

Download         Length: 270 bp

>T182600 NZ_CP086510:655565-655879 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT182600 WP_002326825.1 NZ_CP065430:1199376-1199648 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT182600 NZ_CP086510:655876-656292 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9I2P4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References