Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
Location | 1199376..1199919 | Replicon | chromosome |
Accession | NZ_CP065430 | ||
Organism | Streptococcus suis strain YZDH1 |
Toxin (Protein)
Gene name | zeta | Uniprot ID | A0A1X9I2P4 |
Locus tag | I5V48_RS05855 | Protein ID | WP_002943355.1 |
Coordinates | 1199650..1199919 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | epsilon | Uniprot ID | Q9AL19 |
Locus tag | I5V48_RS05850 | Protein ID | WP_002326825.1 |
Coordinates | 1199376..1199648 (+) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I5V48_RS05805 | 1194665..1194895 | + | 231 | WP_000659121.1 | hypothetical protein | - |
I5V48_RS05810 | 1194966..1195157 | + | 192 | WP_000503424.1 | hypothetical protein | - |
I5V48_RS05815 | 1195211..1196311 | + | 1101 | Protein_1116 | recombinase family protein | - |
I5V48_RS05820 | 1196403..1196642 | + | 240 | WP_000635249.1 | peptide-binding protein | - |
I5V48_RS05825 | 1196691..1196774 | + | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
I5V48_RS05830 | 1196899..1197636 | + | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
I5V48_RS05835 | 1197806..1198066 | + | 261 | Protein_1120 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
I5V48_RS05840 | 1198169..1199065 | + | 897 | WP_002326827.1 | ParA family protein | - |
I5V48_RS05845 | 1199149..1199358 | + | 210 | WP_000527318.1 | peptide-binding protein | - |
I5V48_RS05850 | 1199376..1199648 | + | 273 | WP_002326825.1 | antitoxin | Antitoxin |
I5V48_RS05855 | 1199650..1199919 | + | 270 | WP_002943355.1 | zeta toxin family protein | Toxin |
I5V48_RS05860 | 1200017..1200338 | + | 322 | Protein_1125 | DUF4368 domain-containing protein | - |
I5V48_RS05865 | 1200331..1201290 | + | 960 | Protein_1126 | hypothetical protein | - |
I5V48_RS05870 | 1201361..1201660 | + | 300 | WP_002943350.1 | hypothetical protein | - |
I5V48_RS05875 | 1201674..1201964 | + | 291 | WP_105152240.1 | hypothetical protein | - |
I5V48_RS05880 | 1202060..1202698 | + | 639 | WP_050887020.1 | hypothetical protein | - |
I5V48_RS05885 | 1202738..1203814 | + | 1077 | WP_044758819.1 | toprim domain-containing protein | - |
I5V48_RS05890 | 1203868..1204095 | + | 228 | WP_002943342.1 | hypothetical protein | - |
I5V48_RS05895 | 1204092..1204481 | + | 390 | WP_002943340.1 | hypothetical protein | - |
I5V48_RS05900 | 1204531..1204827 | + | 297 | WP_044758818.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | tet(O) / erm(B) | nanB | 1161951..1343152 | 181201 | |
- | flank | IS/Tn | tet(O) / erm(B) | - | 1190835..1197636 | 6801 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 9999.08 Da Isoelectric Point: 8.7696
>T182600 WP_002943355.1 NZ_CP065430:1199650-1199919 [Streptococcus suis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS
Download Length: 270 bp
>T182600 NZ_CP086510:655565-655879 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10720.17 Da Isoelectric Point: 4.4865
>AT182600 WP_002326825.1 NZ_CP065430:1199376-1199648 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA
Download Length: 273 bp
>AT182600 NZ_CP086510:655876-656292 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X9I2P4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2AF93 |