Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 717726..718395 Replicon chromosome
Accession NZ_CP065430
Organism Streptococcus suis strain YZDH1

Toxin (Protein)


Gene name hicA Uniprot ID G7SGM1
Locus tag I5V48_RS03560 Protein ID WP_014637653.1
Coordinates 717726..717908 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0M9FH26
Locus tag I5V48_RS03565 Protein ID WP_029180323.1
Coordinates 717946..718395 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5V48_RS03540 713084..713233 + 150 WP_043026186.1 50S ribosomal protein L33 -
I5V48_RS03545 713280..713513 + 234 WP_002935768.1 preprotein translocase subunit SecG -
I5V48_RS03550 714049..716418 + 2370 WP_174850209.1 ribonuclease R -
I5V48_RS03555 716421..716888 + 468 WP_002935771.1 SsrA-binding protein SmpB -
I5V48_RS03560 717726..717908 + 183 WP_014637653.1 type II toxin-antitoxin system HicA family toxin Toxin
I5V48_RS03565 717946..718395 + 450 WP_029180323.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I5V48_RS03570 718556..719599 - 1044 WP_174850212.1 alcohol dehydrogenase catalytic domain-containing protein -
I5V48_RS03575 719753..720613 + 861 WP_174850210.1 SAM-dependent methyltransferase TehB -
I5V48_RS03580 720702..722555 + 1854 WP_170238434.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6653.87 Da        Isoelectric Point: 10.8207

>T182598 WP_014637653.1 NZ_CP065430:717726-717908 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T182598 NZ_CP086510:185985-186092 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16638.66 Da        Isoelectric Point: 4.0193

>AT182598 WP_029180323.1 NZ_CP065430:717946-718395 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 450 bp

>AT182598 NZ_CP086510:c185937-185871 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SGM1

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FH26

References