Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 285140..286413 Replicon chromosome
Accession NZ_CP065430
Organism Streptococcus suis strain YZDH1

Toxin (Protein)


Gene name sezT Uniprot ID A0A0Z8I7L1
Locus tag I5V48_RS01390 Protein ID WP_043026612.1
Coordinates 285616..286413 (+) Length 266 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID A0A0Z8FEJ8
Locus tag I5V48_RS01385 Protein ID WP_043026611.1
Coordinates 285140..285616 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5V48_RS01355 280700..281080 + 381 WP_043025465.1 CidA/LrgA family protein -
I5V48_RS01360 281073..281768 + 696 WP_043025463.1 LrgB family protein -
I5V48_RS01365 281802..282602 - 801 WP_043025462.1 formate/nitrite transporter family protein -
I5V48_RS01370 282742..283587 + 846 WP_043025461.1 aquaporin family protein -
I5V48_RS01375 283718..283876 + 159 Protein_238 DUF853 family protein -
I5V48_RS01380 284006..284620 + 615 WP_043025460.1 CoA pyrophosphatase -
I5V48_RS01385 285140..285616 + 477 WP_043026611.1 helix-turn-helix domain-containing protein Antitoxin
I5V48_RS01390 285616..286413 + 798 WP_043026612.1 zeta toxin family protein Toxin
I5V48_RS01395 286410..288029 + 1620 WP_043026614.1 hypothetical protein -
I5V48_RS01400 288016..288558 + 543 WP_043026615.1 hypothetical protein -
I5V48_RS01405 288551..291199 + 2649 WP_197315081.1 SMC family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 265573..323942 58369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 266 a.a.        Molecular weight: 30270.28 Da        Isoelectric Point: 7.4699

>T182597 WP_043026612.1 NZ_CP065430:285616-286413 [Streptococcus suis]
MRLEEFSEADFQKALQRTIRALTRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDKLSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAVDPTQARATPKEHHDGIVENLVDNLRQLEREQLFDQIQIYHRDKTCIYDSERDEGSAAEVLQECLFGQWSKVEKEMM
KVGKERLDKLSTLSKESNGRNYDFI

Download         Length: 798 bp

>T182597 NZ_CP086506:19133-19384 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATCACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGAAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18261.68 Da        Isoelectric Point: 4.3971

>AT182597 WP_043026611.1 NZ_CP065430:285140-285616 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLAPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWVLMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVMA

Download         Length: 477 bp

>AT182597 NZ_CP086506:19371-19598 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8I7L1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8FEJ8

References