Detailed information of TA system TA182596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2394777..2395405
• Replicon: chromosome
• Accession: NZ_CP065428
• Organism: Thalassospira sp. A40-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IT893_RS10935
• Protein ID: WP_197145188.1
• Coordinates: 2395007..2395405 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0D8CG96
• Locus tag: IT893_RS10930
• Protein ID: WP_033067331.1
• Coordinates: 2394777..2395007 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT893_RS10920	2391242..2394349	+	3108	WP_197145186.1	FAD-binding oxidoreductase	-
IT893_RS10925	2394358..2394678	+	321	WP_197145187.1	Dabb family protein	-
IT893_RS10930	2394777..2395007	+	231	WP_033067331.1	antitoxin	Antitoxin
IT893_RS10935	2395007..2395405	+	399	WP_197145188.1	tRNA(fMet)-specific endonuclease VapC	Toxin
IT893_RS10940	2395979..2396383	+	405	WP_197145189.1	hypothetical protein	-
IT893_RS10945	2396846..2397217	-	372	WP_197145190.1	nuclear transport factor 2 family protein	-
IT893_RS10950	2397315..2397635	-	321	WP_197145191.1	hypothetical protein	-
IT893_RS10955	2398005..2399420	-	1416	WP_197145192.1	dihydropyrimidinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14762.98 Da
• Isoelectric Point: 7.3220

>T182596 WP_197145188.1 NZ_CP065428:2395007-2395405 [Thalassospira sp. A40-3]
MLRFMLDTNICIYVIKNRPPSCREKFTTHSGALAISSVTMAELIYGAMKSAKPESNLRTIEEFAARLTVLDFDTNAAGHY
GDIRSNLEAKGTVIGPYDMMIAGHARSHGLILVTNNTREFERVEGLRLENWV

Nucleotide

• Length: 399 bp

>T182596 NZ_CP086505:9618-9878 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACATTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAATCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTATTTTTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8534.60 Da
• Isoelectric Point: 4.4848

>AT182596 WP_033067331.1 NZ_CP065428:2394777-2395007 [Thalassospira sp. A40-3]
MTQASVFLNNKTQAVRLPKDVAFPEGTKTVEVISVGVTRVIVPSDHLWDTFFDGHAVSDDFMEDRNQPAMQEREAL

Nucleotide

• Length: 231 bp

>AT182596 NZ_CP086505:9868-10119 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D8CG96