Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1557983..1558640 Replicon chromosome
Accession NZ_CP065420
Organism Providencia sp. 2.29

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1H2A7
Locus tag I3B46_RS06920 Protein ID WP_036941148.1
Coordinates 1558230..1558640 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID B2Q1I8
Locus tag I3B46_RS06915 Protein ID WP_004921708.1
Coordinates 1557983..1558249 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3B46_RS06900 1553014..1555890 + 2877 WP_004921716.1 aminomethyl-transferring glycine dehydrogenase -
I3B46_RS06905 1556109..1556729 - 621 WP_004921714.1 HD domain-containing protein -
I3B46_RS06910 1556741..1557730 - 990 WP_004921711.1 tRNA-modifying protein YgfZ -
I3B46_RS06915 1557983..1558249 + 267 WP_004921708.1 FAD assembly factor SdhE Antitoxin
I3B46_RS06920 1558230..1558640 + 411 WP_036941148.1 membrane protein Toxin
I3B46_RS06925 1558686..1559204 - 519 WP_014656387.1 flavodoxin FldB -
I3B46_RS06930 1559367..1560290 + 924 WP_004921697.1 site-specific tyrosine recombinase XerD -
I3B46_RS06935 1560310..1561014 + 705 WP_004921696.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I3B46_RS06940 1561020..1562753 + 1734 WP_004921693.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15289.15 Da        Isoelectric Point: 10.8779

>T182593 WP_036941148.1 NZ_CP065420:1558230-1558640 [Providencia sp. 2.29]
VVLWKSNLSISWKTQLFSTCAHGVVGFILLVAPWAPGNSMVWLPLLVIVIASWAKSQKSISKIKGTAVLVNGNKVQWKKN
EWSIVKQPWCSRVGVLLTLSALQGKPQKIRLWVAKDALSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T182593 NZ_CP086503:22067-22369 [Escherichia coli]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTGTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10576.10 Da        Isoelectric Point: 4.9104

>AT182593 WP_004921708.1 NZ_CP065420:1557983-1558249 [Providencia sp. 2.29]
MDIENKARIHWACRRGMRELDISIMPFFEYEYEGLSDKDKRTFVRLLECADPDLFNWLMNHGRPDDDELFGMVKLIQERN
KNRGPVEI

Download         Length: 267 bp

>AT182593 NZ_CP086503:22440-22778 [Escherichia coli]
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1H2A7

Antitoxin

Source ID Structure
AlphaFold DB A0A140NIX0

References