Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 855792..856443 Replicon chromosome
Accession NZ_CP065420
Organism Providencia sp. 2.29

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag I3B46_RS03670 Protein ID WP_004927064.1
Coordinates 855792..855995 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag I3B46_RS03675 Protein ID WP_004927067.1
Coordinates 856075..856443 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3B46_RS03645 851671..852009 + 339 WP_004927053.1 P-II family nitrogen regulator -
I3B46_RS03650 852020..853303 + 1284 WP_014656764.1 ammonium transporter AmtB -
I3B46_RS03655 853540..854406 - 867 WP_004927058.1 acyl-CoA thioesterase II -
I3B46_RS03660 854728..855186 + 459 WP_004927062.1 YbaY family lipoprotein -
I3B46_RS03670 855792..855995 - 204 WP_004927064.1 hemolysin expression modulator Hha Toxin
I3B46_RS03675 856075..856443 - 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
I3B46_RS03680 857011..858348 - 1338 WP_004927077.1 murein transglycosylase D -
I3B46_RS03685 858427..859182 - 756 WP_014656763.1 hydroxyacylglutathione hydrolase -
I3B46_RS03690 859216..859941 + 726 WP_053110025.1 methyltransferase domain-containing protein -
I3B46_RS03695 860020..860490 - 471 WP_104872987.1 ribonuclease HI -
I3B46_RS03700 860545..861306 + 762 WP_004927092.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T182592 WP_004927064.1 NZ_CP065420:c855995-855792 [Providencia sp. 2.29]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T182592 NZ_CP086502:77203-77619 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT182592 WP_004927067.1 NZ_CP065420:c856443-856075 [Providencia sp. 2.29]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp

>AT182592 NZ_CP086502:76976-77206 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References