Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 150035..150780 Replicon chromosome
Accession NZ_CP065420
Organism Providencia sp. 2.29

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag I3B46_RS00640 Protein ID WP_163761890.1
Coordinates 150301..150780 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag I3B46_RS00635 Protein ID WP_123382784.1
Coordinates 150035..150301 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3B46_RS00600 145337..145858 - 522 WP_163761886.1 adhesin -
I3B46_RS00605 145958..146704 - 747 WP_163761887.1 hypothetical protein -
I3B46_RS00610 146828..147130 - 303 WP_163762230.1 helix-turn-helix transcriptional regulator -
I3B46_RS00615 147826..148055 + 230 Protein_116 PAAR domain-containing protein -
I3B46_RS00620 148112..148342 + 231 WP_163761888.1 transposase -
I3B46_RS00625 148409..149041 + 633 WP_163762231.1 IS3 family transposase -
I3B46_RS00630 149205..149840 - 636 WP_163761889.1 recombinase family protein -
I3B46_RS00635 150035..150301 + 267 WP_123382784.1 DUF1778 domain-containing protein Antitoxin
I3B46_RS00640 150301..150780 + 480 WP_163761890.1 GNAT family N-acetyltransferase Toxin
I3B46_RS00645 150898..152382 + 1485 WP_163761891.1 DUF2075 domain-containing protein -
I3B46_RS00650 152489..153193 + 705 WP_121875320.1 IS6 family transposase -
I3B46_RS00655 153200..155437 + 2238 WP_163761892.1 type III secretion system translocon subunit SctE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 136007..153193 17186
- inside IScluster/Tn - - 149205..153193 3988


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(34-148)

Antitoxin

Vibrio phage ICP1, Orf50

(3-87)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17708.39 Da        Isoelectric Point: 10.1267

>T182591 WP_163761890.1 NZ_CP065420:150301-150780 [Providencia sp. 2.29]
VNLQLLAPKPLSSSHRLDDFFCGESSLDDWLKRRALSNHLNGASRTFVIADSYQHVWGYYALATGAISHNEATGRVRRNM
PEPIPVIVLGRFAIDLRAQGRKLGASLLQDAVIRVRAVAENTGVRALLVHALNDKAKQFYEYYGFTASPISPMTLMLRL

Download         Length: 480 bp

>T182591 NZ_CP086502:c76196-75891 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10074.54 Da        Isoelectric Point: 4.2821

>AT182591 WP_123382784.1 NZ_CP065420:150035-150301 [Providencia sp. 2.29]
MRNAAINLRALPEQRDLIDEAASLLGKNRSDFMLEVACERAQAILLDQVFFQLDNEKFQQFNLLLDAPVNSNPGLDRLMS
IETPWKEI

Download         Length: 267 bp

>AT182591 NZ_CP086502:c76416-76198 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References