Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4795899..4796551 Replicon chromosome
Accession NZ_CP065417
Organism Pseudomonas aeruginosa isolate P23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I5U72_RS22240 Protein ID WP_003134109.1
Coordinates 4795899..4796309 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I5U72_RS22245 Protein ID WP_170869361.1
Coordinates 4796309..4796551 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5U72_RS22195 4790935..4792260 + 1326 WP_191519258.1 hypothetical protein -
I5U72_RS22200 4792308..4792660 + 353 Protein_4397 hypothetical protein -
I5U72_RS22205 4792572..4792769 + 198 WP_009315864.1 hypothetical protein -
I5U72_RS22210 4792926..4793654 + 729 WP_009315862.1 TIGR03761 family integrating conjugative element protein -
I5U72_RS22215 4793660..4794190 + 531 WP_121372660.1 DUF3158 family protein -
I5U72_RS22220 4794204..4794692 + 489 WP_023104904.1 single-stranded DNA-binding protein -
I5U72_RS22225 4795191..4795388 + 198 WP_191519259.1 CrpP family protein -
I5U72_RS22230 4795454..4795672 - 219 WP_023083218.1 hypothetical protein -
I5U72_RS22235 4795722..4795883 - 162 WP_191519260.1 hypothetical protein -
I5U72_RS22240 4795899..4796309 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
I5U72_RS22245 4796309..4796551 - 243 WP_170869361.1 antitoxin Antitoxin
I5U72_RS22250 4796857..4798782 + 1926 WP_191519261.1 type I DNA topoisomerase -
I5U72_RS22255 4798790..4799542 + 753 WP_191519262.1 hypothetical protein -
I5U72_RS22260 4799654..4801543 + 1890 WP_191519263.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katA 4777436..4904284 126848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(11-37)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T182588 WP_003134109.1 NZ_CP065417:c4796309-4795899 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T182588 NZ_CP086501:2255-2533 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8909.94 Da        Isoelectric Point: 4.4230

>AT182588 WP_170869361.1 NZ_CP065417:c4796551-4796309 [Pseudomonas aeruginosa]
MRCVVEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 243 bp

>AT182588 NZ_CP086501:1986-2255 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References