Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3716722..3717942 Replicon chromosome
Accession NZ_CP065417
Organism Pseudomonas aeruginosa isolate P23

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I5U72_RS16950 Protein ID WP_003160088.1
Coordinates 3717364..3717942 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I5U72_RS16945 Protein ID WP_003088112.1
Coordinates 3716722..3717276 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5U72_RS16920 3712290..3712841 + 552 WP_003132721.1 XRE family transcriptional regulator -
I5U72_RS16925 3712838..3713236 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
I5U72_RS16930 3713249..3713572 - 324 WP_003102734.1 multidrug efflux SMR transporter -
I5U72_RS16935 3713903..3714364 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
I5U72_RS16940 3714369..3716564 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
I5U72_RS16945 3716722..3717276 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
I5U72_RS16950 3717364..3717942 + 579 WP_003160088.1 HD domain-containing protein Toxin
I5U72_RS16955 3718051..3719238 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
I5U72_RS16960 3719228..3721399 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
I5U72_RS16965 3721389..3722666 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T182586 WP_003160088.1 NZ_CP065417:3717364-3717942 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T182586 NZ_CP086500:c4244118-4243768 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT182586 WP_003088112.1 NZ_CP065417:3716722-3717276 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT182586 NZ_CP086500:c4244363-4244112 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References