Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 176102..176607 Replicon chromosome
Accession NZ_CP065417
Organism Pseudomonas aeruginosa isolate P23

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag I5U72_RS00815 Protein ID WP_003121619.1
Coordinates 176102..176383 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag I5U72_RS00820 Protein ID WP_003112628.1
Coordinates 176380..176607 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I5U72_RS00790 171353..172702 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
I5U72_RS00795 172751..173437 + 687 WP_003083762.1 FadR family transcriptional regulator -
I5U72_RS00800 173538..174272 + 735 WP_003117208.1 GntR family transcriptional regulator -
I5U72_RS00805 174476..174862 + 387 WP_014602345.1 aegerolysin family protein -
I5U72_RS00810 174894..175802 - 909 WP_016561475.1 LysR family transcriptional regulator -
I5U72_RS00815 176102..176383 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
I5U72_RS00820 176380..176607 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
I5U72_RS00825 176783..177403 - 621 WP_003101226.1 hypothetical protein -
I5U72_RS00830 177504..178004 + 501 WP_003112629.1 LEA type 2 family protein -
I5U72_RS00835 178077..178418 + 342 WP_003101229.1 alkylphosphonate utilization protein -
I5U72_RS00840 178500..179927 - 1428 WP_003083784.1 GABA permease -
I5U72_RS00845 180096..181589 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T182583 WP_003121619.1 NZ_CP065417:c176383-176102 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T182583 NZ_CP086500:c3786622-3786224 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT182583 WP_003112628.1 NZ_CP065417:c176607-176380 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT182583 NZ_CP086500:c3786918-3786625 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References