Detailed information of TA system TA182582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 1439..1989
• Replicon: plasmid pP33-2
• Accession: NZ_CP065414
• Organism: Pseudomonas aeruginosa isolate P33

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I5U70_RS33045
• Protein ID: WP_019727125.1
• Coordinates: 1439..1714 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6B1YL09
• Locus tag: I5U70_RS33050
• Protein ID: WP_019727126.1
• Coordinates: 1714..1989 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5U70_RS33035	130..450	+	321	WP_196994198.1	hypothetical protein	-
I5U70_RS33040	932..1348	+	417	WP_196994199.1	hypothetical protein	-
I5U70_RS33045	1439..1714	-	276	WP_019727125.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I5U70_RS33050	1714..1989	-	276	WP_019727126.1	ribbon-helix-helix protein, CopG family	Antitoxin
I5U70_RS33055	2264..2650	+	387	WP_019727127.1	hypothetical protein	-
I5U70_RS33060	2711..3004	+	294	WP_019727128.1	hypothetical protein	-
I5U70_RS33065	3328..3636	+	309	WP_019727129.1	hypothetical protein	-
I5U70_RS33070	4286..4738	+	453	WP_019727132.1	DNA repair protein RadC	-
I5U70_RS33075	5176..5424	+	249	WP_058130600.1	hypothetical protein	-
I5U70_RS33080	5474..5725	-	252	WP_058130599.1	hypothetical protein	-
I5U70_RS33085	5784..6068	+	285	WP_019727136.1	hypothetical protein	-
I5U70_RS33090	6111..6488	+	378	WP_019727137.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..48306	48306

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 13558.26 Da
• Isoelectric Point: 5.5500

>T182582 WP_019727125.1 NZ_CP065414:c1714-1439 [Pseudomonas aeruginosa]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFF

Nucleotide

• Length: 276 bp

>T182582 NZ_CP086500:3573993-3574211 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 13558.26 Da
• Isoelectric Point: 5.5500

>AT182582 WP_019727126.1 NZ_CP065414:c1989-1714 [Pseudomonas aeruginosa]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFF

Nucleotide

• Length: 276 bp

>AT182582 NZ_CP086500:3573593-3573967 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A6B1YL09